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Literature summary extracted from

  • Takada, R.; Satomi, Y.; Kurata, T.; Ueno, N.; Norioka, S.; Kondoh, H.; Takao, T.; Takada, S.
    Monounsaturated fatty acid modification of Wnt p+rotein: its role in Wnt secretion (2006), Dev. Cell, 11, 791-801.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.250 endoplasmic reticulum membrane
-
 Drosophila melanogaster 5789
-
2.3.1.250 endoplasmic reticulum membrane
-
 Mus musculus 5789
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine Drosophila melanogaster the enzyme catalyzes the palmitoylation of Ser209 and Cys77 of Wnt3a CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine Mus musculus the enzyme catalyzes the palmitoylation of Ser209 and Cys77 of Wnt3a expressed in L cells CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.250 Drosophila melanogaster
-
 gene porc
-
2.3.1.250 Mus musculus
-
 gene porc
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.250 L-929 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine the enzyme catalyzes the palmitoylation of Ser209 and Cys77 of Wnt3a Drosophila melanogaster CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine the enzyme catalyzes the palmitoylation of Ser209 and Cys77 of Wnt3a Mus musculus CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine the enzyme catalyzes the palmitoylation of Ser209 and Cys77 of Wnt3a expressed in L cells Mus musculus CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.250 PORC
-
 Drosophila melanogaster
2.3.1.250 PORC
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.3.1.250 evolution the enzyme belongs to the family of membrane-bound O-acyltransferases (MBOAT), which transfer acyl groups, such as a palmitoyl group, to substrates Drosophila melanogaster
2.3.1.250 evolution the enzyme belongs to the family of membrane-bound O-acyltransferases (MBOAT), which transfer acyl groups, such as a palmitoyl group, to substrates Mus musculus
2.3.1.250 malfunction treatment with a chemical inhibitor of acyltransferases produces defective intracellular trafficking of Wingless Drosophila melanogaster
2.3.1.250 malfunction Wnt-3a with defective acylation is not transferred from the endoplasmic reticulum Mus musculus
2.3.1.250 physiological function enzyme overexpression in culture cells enhances the intracellular processing, for example, N-glycosylation, of Wingless, the Drosophila Wnt1 analogue Drosophila melanogaster
2.3.1.250 physiological function porcupine is required for the acylation and secretion of Wnt-3a, porc-dependent acylation may regulate the processing and intracellular trafficking of Wnt, although acylation at Cys77 does not appear to be involved in these processes Mus musculus