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Literature summary extracted from

  • La, T.; Clark-Walker, G.D.; Wang, X.; Wilkens, S.; Chen, X.J.
    Mutations on the N-terminal edge of the DELSEED loop in either the alpha or beta subunit of the mitochondrial F1-ATPase enhance ATP hydrolysis in the absence of the central gamma rotor (2013), Eukaryot. Cell, 12, 1451-1461.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.1.2.2 mutant enzymes are expressed in Kluyveromyces lactis mutant lacking the gamma rotor Kluyveromyces lactis

Protein Variants

EC Number Protein Variants Comment Organism
7.1.2.2 F446I the mutation in the alpha subunit suppresses cell death by the loss of mitochondrial DNA in a Kluyveromyces lactis mutant lacking the gamma rotor subunit Kluyveromyces lactis
7.1.2.2 G419D the mutation in the beta subunit suppresses cell death by the loss of mitochondrial DNA in a Kluyveromyces lactis mutant lacking the gamma rotor subunit Kluyveromyces lactis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.2.2 ATP + H2O + H+/in Kluyveromyces lactis
-
 ADP + phosphate + H+/out
-
 ?
7.1.2.2 ATP + H2O + H+/in Kluyveromyces lactis PM6-7A
-
 ADP + phosphate + H+/out
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.1.2.2 Kluyveromyces lactis
-
-
-
7.1.2.2 Kluyveromyces lactis PM6-7A
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
7.1.2.2 nickel affinity column chromatography and gel filtration Kluyveromyces lactis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.2.2 ATP + H2O + H+/in
-
 Kluyveromyces lactis ADP + phosphate + H+/out
-
 ?
7.1.2.2 ATP + H2O + H+/in
-
 Kluyveromyces lactis PM6-7A ADP + phosphate + H+/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.2.2 F1-ATPase
-
 Kluyveromyces lactis