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Literature summary extracted from

  • Liu, H.Y.; Pfleger, C.M.
    Mutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment (2013), PLoS ONE, 8, e32835.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.45 genotyping-phenotyping Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
6.2.1.45 additional information genotyping-phenotyping Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.45 cytosol
-
 Drosophila melanogaster 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.45 Mg2+ required Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.45 ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine Drosophila melanogaster
-
 AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.45 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.45 brain
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.45 ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine
-
 Drosophila melanogaster AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.45 E1
-
 Drosophila melanogaster
6.2.1.45 Uba1
-
 Drosophila melanogaster
6.2.1.45 ubiquitin activating enzyme
-
 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.45 ATP
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
6.2.1.45 malfunction identification of loss-of-function mutations in the Drosophila ubiquitin activating enzyme, the most upstream enzyme in the ubiquitin pathway. Loss of only one functional copy of E1 caused a significant reduction in adult lifespan. Rare homozygous hypomorphic E1 mutants reach adulthood, but mutants exhibit further reduced lifespan and show inappropriate Ras activation in the brain. Removing just one functional copy of Ras restores the lifespan of heterozygous E1 mutants to that of wild-type flies and increase the survival of homozygous E1 mutants. E1 homozygous mutants also show severe motor impairment involved in early mortality. Phenotypes, detailed overview Drosophila melanogaster