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Literature summary extracted from

  • Han, S.J.; Jang, H.S.; Noh, M.R.; Kim, J.; Kong, M.J.; Kim, J.I.; Park, J.W.; Park, K.M.
    Mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency exacerbates mitochondrial and cell damage after kidney ischemia-reperfusion injury (2017), J. Am. Soc. Nephrol., 28, 1200-1215.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.42 additional information Idh2 gene deletion, generation of Idh2-/- mice, phenotype,overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.42 additional information ischemia-reperfusion reduces IDH2 expression and activity in both Idh2+/+ and Idh2-/- kidneys Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.42 mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.42 isocitrate + NADP+ Mus musculus
-
 2-oxoglutarate + CO2 + NADPH + H+
-
 r
1.1.1.42 isocitrate + NADP+ Mus musculus C57BL/6
-
 2-oxoglutarate + CO2 + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.42 Mus musculus P54071
-
-
1.1.1.42 Mus musculus C57BL/6 P54071
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.42 kidney
-
 Mus musculus
-
1.1.1.42 renal proximal tubule cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.42 isocitrate + NADP+
-
 Mus musculus 2-oxoglutarate + CO2 + NADPH + H+
-
 r
1.1.1.42 isocitrate + NADP+
-
 Mus musculus C57BL/6 2-oxoglutarate + CO2 + NADPH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.42 IDH2
-
 Mus musculus
1.1.1.42 NADP+-dependent isocitrate dehydrogenase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.42 NADP+
-
 Mus musculus
1.1.1.42 NADPH
-
 Mus musculus

Expression

EC Number Organism Comment Expression
1.1.1.42 Mus musculus ischemia-reperfusion reduces IDH2 expression and activity in both Idh2+/+ and Idh2-/- kidneys. IDH1 expression decreases 1 day after ischemia and then returns to around normal level by 16 days after ischemia down

General Information

EC Number General Information Comment Organism
1.1.1.42 malfunction mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency exacerbates mitochondrial and cell damage after kidney ischemia-reperfusion injury, Idh2 gene deletion exacerbates ROS production and oxidative stress after ischemia-reperfusion, and causes I/R-induced mitochondrial dysfunction and morphologic fragmentation, resulting in severe apoptosis in kidney tubule cells, it impairs reduction of NADP+ and GSSG within mitochondria Mus musculus
1.1.1.42 physiological function mitochondrial NADP+-dependent isocitrate dehydrogenase (IDH2) catalyzes the oxidative decarboxylation of isocitrate to 2-oxooglutarate, synthesizing NADPH, which is essential for mitochondrial redox balance Mus musculus