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Literature summary extracted from

  • Muskal, S.M.; Sliman, J.; Kokai-Kun, J.; Pimentel, M.; Wacher, V.; Gottlieb, K.
    Lovastatin lactone may improve irritable bowel syndrome with constipation (IBS-C) by inhibiting enzymes in the archaeal methanogenesis pathway (2016), F1000Res., 5, 606 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.98.1 lovastatin
-
 Methanobrevibacter smithii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.98.1 5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420 Methanobrevibacter smithii
-
 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
 ?
1.5.98.1 5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420 Methanobrevibacter smithii ATCC 35061
-
 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.98.1 Methanobrevibacter smithii A5UMI1
-
-
1.5.98.1 Methanobrevibacter smithii ATCC 35061 A5UMI1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.98.1 5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
-
 Methanobrevibacter smithii 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
 ?
1.5.98.1 5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420
-
 Methanobrevibacter smithii ATCC 35061 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.98.1 coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase
-
 Methanobrevibacter smithii
1.5.98.1 methylene-H(4)MPT dehydrogenase
-
 Methanobrevibacter smithii
1.5.98.1 MTD
-
 Methanobrevibacter smithii

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.98.1 coenzyme F420
-
 Methanobrevibacter smithii