EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.47 | 3-[[(3,4-dichlorophenyl)carbamoyl]amino]benzoic acid | inhibits both isoforms CysK1 and CysK2 and O-phosphoserine sulfhydrylase CysM | Mycobacterium tuberculosis | |
2.5.1.47 | 3-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]benzoic acid | inhibits both isoforms CysK1 and CysK2 and O-phosphoserine sulfhydrylase CysM | Mycobacterium tuberculosis | |
2.5.1.47 | 4-[[(3,4-dichlorophenyl)carbamoyl]amino]-2-hydroxybenzoic acid | selective for isoform CysK1, IC50 value for isoform CysK2 above 300 microM | Mycobacterium tuberculosis | |
2.5.1.47 | 4-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]-2-hydroxybenzoic acid | inhibits both isoforms CysK1 and CysK2 and O-phosphoserine sulfhydrylase CysM | Mycobacterium tuberculosis | |
2.5.1.47 | 5-[[(3,4-dichlorophenyl)carbamoyl]amino]-2-hydroxybenzoic acid | inhibits both isoforms CysK1 and CysK2 | Mycobacterium tuberculosis | |
2.5.1.47 | 5-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]-2-hydroxybenzoic acid | inhibits both isoforms CysK1 and CysK2 and O-phosphoserine sulfhydrylase CysM | Mycobacterium tuberculosis | |
2.5.1.144 | 1-(3,4-dichlorophenyl)-3-[3-(1H-tetrazol-5-yl)phenyl]urea | weak inhibitor | Mycobacterium tuberculosis | |
2.5.1.144 | 2-[[(2,5-dimethoxyphenyl)carbamoyl]amino]benzoic acid | weak inhibitor | Mycobacterium tuberculosis | |
2.5.1.144 | 3-[[(3',4'-dichlorobiphenyl-3-yl)sulfonyl]amino]benzoic acid | weak inhibitor | Mycobacterium tuberculosis | |
2.5.1.144 | 3-[[(3,4-dichlorophenyl)carbamoyl]amino]benzoic acid | - |
Mycobacterium tuberculosis | |
2.5.1.144 | 3-[[(3-benzylphenyl)carbamoyl]amino]benzoic acid | - |
Mycobacterium tuberculosis | |
2.5.1.144 | 3-[[(4-bromophenyl)carbamoyl]amino]benzoic acid | - |
Mycobacterium tuberculosis | |
2.5.1.144 | 3-[[(4-chlorophenyl)carbamoyl]amino]benzoic acid | - |
Mycobacterium tuberculosis | |
2.5.1.144 | 3-[[(4-methylphenyl)carbamoyl]amino]benzoic acid | - |
Mycobacterium tuberculosis | |
2.5.1.144 | 4-[[(3-benzylphenyl)carbamoyl]amino]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
2.5.1.144 | 4-[[(4-bromophenyl)carbamoyl]amino]-2-hydroxybenzoic acid | weak inhibitor | Mycobacterium tuberculosis | |
2.5.1.144 | 5-[[(3,4-dichlorophenyl)carbamoyl]amino]-2-hydroxybenzoic acid | weak inhibitor | Mycobacterium tuberculosis | |
2.5.1.144 | 5-[[(3-benzylphenyl)carbamoyl]amino]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
2.8.5.1 | 2-[[(2,5-dimethoxyphenyl)carbamoyl]amino]benzoic acid | - |
Mycobacterium tuberculosis | |
2.8.5.1 | 3-[(3',4'-dichloro[1,1'-biphenyl]-3-sulfonyl)amino]benzoic acid | - |
Mycobacterium tuberculosis | |
2.8.5.1 | 3-[[(3,4-dichlorophenyl)carbamoyl]amino]benzoic acid | - |
Mycobacterium tuberculosis | |
2.8.5.1 | 3-[[(4-bromophenyl)carbamoyl]amino]benzoic acid | - |
Mycobacterium tuberculosis | |
2.8.5.1 | 3-[[(4-chlorophenyl)carbamoyl]amino]benzoic acid | - |
Mycobacterium tuberculosis | |
2.8.5.1 | 3-[[(4-methylphenyl)carbamoyl]amino]benzoic acid | - |
Mycobacterium tuberculosis | |
2.8.5.1 | 3-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]benzoic acid | - |
Mycobacterium tuberculosis | |
2.8.5.1 | 4-[[(4-bromophenyl)carbamoyl]amino]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
2.8.5.1 | 4-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
2.8.5.1 | 5-[[(3,4-dichlorophenyl)carbamoyl]amino]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
2.8.5.1 | 5-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
2.8.5.1 | N-(3,4-dichlorophenyl)-N'-[3-(1H-tetrazol-5-yl)phenyl]urea | - |
Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.144 | O-acetyl-L-serine + thiosulfate | Mycobacterium tuberculosis | - |
S-sulfo-L-cysteine + acetate | - |
? | |
2.8.5.1 | 3-phospho-L-serine + thiosulfate | Mycobacterium tuberculosis | - |
S-sulfo-L-cysteine + phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.47 | Mycobacterium tuberculosis | Q79FV4 | isoform CysK2 | - |
2.5.1.47 | Mycobacterium tuberculosis ATCC 25618 | Q79FV4 | isoform CysK2 | - |
2.5.1.144 | Mycobacterium tuberculosis | - |
- |
- |
2.8.5.1 | Mycobacterium tuberculosis | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.144 | O-acetyl-L-serine + thiosulfate | - |
Mycobacterium tuberculosis | S-sulfo-L-cysteine + acetate | - |
? | |
2.8.5.1 | 3-phospho-L-serine + thiosulfate | - |
Mycobacterium tuberculosis | S-sulfo-L-cysteine + phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.47 | CysK2 | - |
Mycobacterium tuberculosis |
2.5.1.144 | CysM | - |
Mycobacterium tuberculosis |
2.8.5.1 | CysK2 | - |
Mycobacterium tuberculosis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.144 | pyridoxal 5'-phosphate | - |
Mycobacterium tuberculosis | |
2.8.5.1 | pyridoxal 5'-phosphate | - |
Mycobacterium tuberculosis |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.5.1.47 | 0.0066 | - |
pH not specified in the publication, temperature not specified in the publication | Mycobacterium tuberculosis | 3-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]benzoic acid | |
2.5.1.47 | 0.0101 | - |
pH not specified in the publication, temperature not specified in the publication | Mycobacterium tuberculosis | 3-[[(3,4-dichlorophenyl)carbamoyl]amino]benzoic acid | |
2.5.1.47 | 0.0103 | - |
pH not specified in the publication, temperature not specified in the publication | Mycobacterium tuberculosis | 5-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]-2-hydroxybenzoic acid | |
2.5.1.47 | 0.0269 | - |
pH not specified in the publication, temperature not specified in the publication | Mycobacterium tuberculosis | 4-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]-2-hydroxybenzoic acid | |
2.5.1.47 | 0.0299 | - |
pH not specified in the publication, temperature not specified in the publication | Mycobacterium tuberculosis | 5-[[(3,4-dichlorophenyl)carbamoyl]amino]-2-hydroxybenzoic acid | |
2.8.5.1 | 0.0066 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 3-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]benzoic acid | |
2.8.5.1 | 0.0101 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 3-[[(3,4-dichlorophenyl)carbamoyl]amino]benzoic acid | |
2.8.5.1 | 0.0103 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 5-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]-2-hydroxybenzoic acid | |
2.8.5.1 | 0.013 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 3-[[(4-chlorophenyl)carbamoyl]amino]benzoic acid | |
2.8.5.1 | 0.0269 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 4-[[([1,1'-biphenyl]-3-yl)carbamoyl]amino]-2-hydroxybenzoic acid | |
2.8.5.1 | 0.0276 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 3-[[(4-bromophenyl)carbamoyl]amino]benzoic acid | |
2.8.5.1 | 0.0299 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 5-[[(3,4-dichlorophenyl)carbamoyl]amino]-2-hydroxybenzoic acid |