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Literature summary extracted from

  • Sanchez-Tarin, M.; Swiderek, K.; Roca, M.; Tunon, I.
    Enzyme promiscuity in enolase superfamily. Theoretical study of o-succinylbenzoate synthase using QM/MM methods (2015), J. Phys. Chem. B, 119, 1899-1911 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.113 (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate Amycolatopsis sp.
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 2-succinylbenzoate + H2O
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 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.113 Amycolatopsis sp. Q44244
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.113 (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
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 Amycolatopsis sp. 2-succinylbenzoate + H2O
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 ?
4.2.1.113 additional information the enzyme catalyzes not only the dehydration of (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate but also catalyzes racemization of different acylamino acids, with N-succinyl-R-phenylglycine being the best substrate, molecular mechanisms for both reactions exploring the potential energy surface, and molecular dynamics simulations to obtain the free energy profiles and the averaged interaction energies of enzymatic residues with the reacting system, overview Amycolatopsis sp. ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.113 menC
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 Amycolatopsis sp.
4.2.1.113 OSBS
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 Amycolatopsis sp.

General Information

EC Number General Information Comment Organism
4.2.1.113 additional information enzyme promiscuity in enolase superfamily is analyzed by using quantum mechanics/molecular mechanics (QM/MM) methods, using both density functional theory and semiempirical Hamiltonians. Presence of flexible loops in the active site and the selection of structural modifications in the substrate seem to be key elements to promote the promiscuity of this enzyme, role played by the different residues in each of the two possible reactions, overview Amycolatopsis sp.