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Literature summary extracted from

  • Tsai, H.H.; Rodriguez-Celma, J.; Lan, P.; Wu, Y.C.; Velez-Bermudez, I.C.; Schmidt, W.
    Scopoletin 8-hydroxylase-mediated fraxetin production is crucial for iron mobilization (2018), Plant Physiol., 177, 194-207 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.60 scopoletin + 2-oxoglutarate + O2 Arabidopsis thaliana the enzyme participates in Fe acquisition by mediating the biosynthesis of fraxetin (7,8-dihydroxy-6-methoxycoumarin), a coumarin derived from the scopoletin pathway fraxetin + succinate + CO2
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.60 Arabidopsis thaliana Q9LE86
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.60 scopoletin + 2-oxoglutarate + O2
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 Arabidopsis thaliana fraxetin + succinate + CO2
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 ?
1.14.11.60 scopoletin + 2-oxoglutarate + O2 the enzyme participates in Fe acquisition by mediating the biosynthesis of fraxetin (7,8-dihydroxy-6-methoxycoumarin), a coumarin derived from the scopoletin pathway Arabidopsis thaliana fraxetin + succinate + CO2
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.60 At3g12900
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 Arabidopsis thaliana
1.14.11.60 S8H
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 Arabidopsis thaliana

Expression

EC Number Organism Comment Expression
1.14.11.60 Arabidopsis thaliana the enzyme is highly induced in roots of Fe-deficient plants both at the transcript and protein levels up

General Information

EC Number General Information Comment Organism
1.14.11.60 malfunction mutants defective in the expression of S8H show increased sensitivity to growth on pH 7.0 media supplemented with an immobile source of Fe and reduced secretion of fraxetin. Transgenic lines overexpressing S8H exhibit an opposite phenotype. Supplementing the media containing immobile Fe with fraxetin partially rescues the s8h mutants Arabidopsis thaliana
1.14.11.60 metabolism the enzyme participates in Fe acquisition by mediating the biosynthesis of fraxetin (7,8-dihydroxy-6-methoxycoumarin), a coumarin derived from the scopoletin pathway. Fraxetin secretion is a decisive factor for calcicole-calcifuge behavior (i.e. the ability/inability to thrive on alkaline soils) of plants Arabidopsis thaliana
1.14.11.60 physiological function the enzyme participates in Fe acquisition by mediating the biosynthesis of fraxetin (7,8-dihydroxy-6-methoxycoumarin), a coumarin derived from the scopoletin pathway. Fraxetin secretion is a decisive factor for calcicole-calcifuge behavior (i.e. the ability/inability to thrive on alkaline soils) of plants Arabidopsis thaliana