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Literature summary extracted from

  • Saint-Marc, C.; Huerlimann, H.C.; Daignan-Fornier, B.; Pinson, B.
    Serine hydroxymethyltransferase a key player connecting purine, folate and methionine metabolism in Saccharomyces cerevisiae (2015), Curr. Genet., 61, 633-640 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O Saccharomyces cerevisiae
-
 tetrahydrofolate + L-serine
-
 r
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O Saccharomyces cerevisiae BY4741
-
 tetrahydrofolate + L-serine
-
 r
2.1.2.1 tetrahydrofolate + L-serine Saccharomyces cerevisiae
-
 5,10-methylenetetrahydrofolate + glycine + H2O
-
 r
2.1.2.1 tetrahydrofolate + L-serine Saccharomyces cerevisiae BY4741
-
 5,10-methylenetetrahydrofolate + glycine + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Saccharomyces cerevisiae
-
-
-
2.1.2.1 Saccharomyces cerevisiae BY4741
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O
-
 Saccharomyces cerevisiae tetrahydrofolate + L-serine
-
 r
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O
-
 Saccharomyces cerevisiae BY4741 tetrahydrofolate + L-serine
-
 r
2.1.2.1 tetrahydrofolate + L-serine
-
 Saccharomyces cerevisiae 5,10-methylenetetrahydrofolate + glycine + H2O
-
 r
2.1.2.1 tetrahydrofolate + L-serine
-
 Saccharomyces cerevisiae BY4741 5,10-methylenetetrahydrofolate + glycine + H2O
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.1.2.1 serine hydroxymethyltransferase
-
 Saccharomyces cerevisiae
2.1.2.1 SHM2
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.1 pyridoxal 5'-phosphate
-
 Saccharomyces cerevisiae

Expression

EC Number Organism Comment Expression
2.1.2.1 Saccharomyces cerevisiae 5-amino-4-imidazole carboxamide ribonucleotide 5'-phosphate stimulates the transcriptional expression of the enzyme up

General Information

EC Number General Information Comment Organism
2.1.2.1 metabolism Shm2 is a key enzyme at the crossing point between purine, methionine and folate metabolism Saccharomyces cerevisiae