EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.1.1.42 | mitochondrion | - |
Mus musculus | 5739 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.42 | isocitrate + NADP+ | Mus musculus | - |
2-oxoglutarate + CO2 + NADPH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.42 | Mus musculus | P54071 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.42 | kidney | - |
Mus musculus | - |
1.1.1.42 | renal tubule | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.42 | isocitrate + NADP+ | - |
Mus musculus | 2-oxoglutarate + CO2 + NADPH + H+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.42 | ? | x * 45000, SDS-PAGE | Mus musculus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.42 | IDH2 | - |
Mus musculus |
1.1.1.42 | NADP+-dependent isocitrate dehydrogenase | - |
Mus musculus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.42 | NADP+ | - |
Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.1.1.42 | malfunction | enzyme deficiency increases cisplatin-induced oxidative damage in kidney tubule cells, inducing more severe nephrotoxicity | Mus musculus |
1.1.1.42 | physiological function | the enzyme is critical in the NADPH-associated mitochondrial antioxidant system and is involved in cisplatin nephrotoxicity. The mitochondrial enzyme-NADPH-glutathione antioxidant system is a target for the prevention of cisplatin-induced kidney cell death | Mus musculus |