Literature summary extracted from

Wang, S.; He, Z.; Yuan, Q.
Xylose enhances furfural tolerance in Candida tropicalis by improving NADH recycle (2017), Chem. Eng. Sci., 158, 37-40 .

No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.B19	additional information	Candida tropicalis	Candida tropicalis can use xylose in hemicellulose hydrolysate	?	-	-
1.1.1.B19	xylitol + NAD+	Candida tropicalis	-	L-xylulose + NADH + H+	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.B19	Candida tropicalis	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.B19	additional information	Candida tropicalis can use xylose in hemicellulose hydrolysate	Candida tropicalis	?	-	-
1.1.1.B19	additional information	xylitol dehydrogenase almost exclusively uses NAD+ as cofactor in the dehydrogenation of xylitol into xylulose	Candida tropicalis	?	-	-
1.1.1.B19	xylitol + NAD+	-	Candida tropicalis	L-xylulose + NADH + H+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.B19	xylitol dehydrogenase	-	Candida tropicalis

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.B19	NAD+	xylitol dehydrogenase almost exclusively uses NAD+ as cofactor in the dehydrogenation of xylitol into xylulose	Candida tropicalis

General Information

EC Number	General Information	Comment	Organism
1.1.1.B19	physiological function	furfural is one of the typical inhibitors present in hemicellulose hydrolysate. Furfural is harmful to cell growth and biofuel production in microbes. Candida tropicalis obtains better furfural tolerance in xylose medium. The dehydrogenation of xylitol, which produces coenzyme NADH, promotes the recycle of NAD+ and facilitates the reduction of furfural. The rate of furfural degradation and half maximal inhibitory concentration for furfural of Candida tropicalis in xylose medium increases 1.68fold and 1.19fold, respectively	Candida tropicalis

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Release 2023.1 (January 2023)