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Literature summary extracted from

  • Grings, M.; Parmeggiani, B.; Moura, A.P.; de Moura Alvorcem, L.; Wyse, A.T.S.; Wajner, M.; Leipnitz, G.
    Evidence that thiosulfate inhibits creatine kinase activity in rat striatum via thiol group oxidation (2018), Neurotox. Res., 34, 693-705 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.3.2 4-hydroxymercuribenzoic acid
-
 Rattus norvegicus
2.7.3.2 thiosulfate 0.5 mM thiosulfate administration decreases the enzyme activity 30 min after administration. Thiosulfate also decreases the activity of the enzyme in vitro in striatum of rats, which is prevented by the thiol reducing agents dithiothreitol, the antioxidants glutathione, melatonin, trolox, and lipoic acid; thiosulfate (1 M) inhibits creatine kinase activity in rat striatum via thiol group oxidation is prevented by the thiol reducing agents dithiothreitol GSH, melatonin, trolox and lipoic acid Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.3.2 ADP + phosphocreatine Rattus norvegicus
-
 ATP + creatine
-
 r
2.7.3.2 ATP + creatine Rattus norvegicus
-
 ADP + phosphocreatine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.3.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.3.2 corpus striatum
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.3.2 ADP + phosphocreatine
-
 Rattus norvegicus ATP + creatine
-
 r
2.7.3.2 ATP + creatine
-
 Rattus norvegicus ADP + phosphocreatine
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.3.2 ATP
-
 Rattus norvegicus