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Literature summary extracted from

  • Marcel, Y.L.; Suzue, G.
    Kinetic studies on the specificity of long chain acyl coenzyme A synthetase from rat liver microsomes (1972), J. Biol. Chem., 247, 4433-4436.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.3 (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid competitive inhibitor of palmitoleic acid activation Rattus norvegicus
6.2.1.3 Eicosa-11,14,17-trienoic acid competitive inhibitor of palmitoleic acid activation Rattus norvegicus
6.2.1.3 eicosa-8,11,14-trienoic acid competitive inhibitor of palmitoleic acid activation Rattus norvegicus
6.2.1.3 Eicosa-8,14-dienoic acid competitive inhibitor of palmitoleic acid activation Rattus norvegicus
6.2.1.3 palmitate linolenic acid activation Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.3 0.00139
-
 oleate
-
 Rattus norvegicus
6.2.1.3 0.00164
-
 linolenate
-
 Rattus norvegicus
6.2.1.3 0.00204
-
 palmitoleate
-
 Rattus norvegicus
6.2.1.3 0.00222
-
 linoleate
-
 Rattus norvegicus
6.2.1.3 0.00278
-
 palmitate
-
 Rattus norvegicus
6.2.1.3 0.0072
-
 CoA activation of palmitic acid Rattus norvegicus
6.2.1.3 0.0094
-
 CoA activation of oleic acid Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.3 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.3 Mg2+ required Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.3 ATP + linoleate + CoA
-
 Rattus norvegicus AMP + diphosphate + linoleoyl-CoA
-
 ?
6.2.1.3 ATP + linolenate + CoA
-
 Rattus norvegicus AMP + diphosphate + linolenoyl-CoA
-
 ?
6.2.1.3 ATP + oleate + CoA
-
 Rattus norvegicus AMP + diphosphate + oleoyl-CoA
-
 ?
6.2.1.3 ATP + palmitate + CoA
-
 Rattus norvegicus AMP + diphosphate + palmitoyl-CoA
-
 ?
6.2.1.3 ATP + palmitoleate + CoA
-
 Rattus norvegicus AMP + diphosphate + palmitoleoyl-CoA
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
6.2.1.3 45
-
 half-life: 15 min Rattus norvegicus