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Literature summary extracted from

  • Goftari, S.N.; Sadeghian, H.; Bahrami, A.R.; Maleki, F.; Matin, M.M.
    Stylosin and some of its synthetic derivatives induce apoptosis in prostate cancer cells as 15-lipoxygenase enzyme inhibitors (2019), Naunyn Schmiedebergs Arch. Pharmacol., 392, 1491-1502 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.12 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine
-
 Homo sapiens
1.13.11.12 adamantyl caffeate IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.074 mM Homo sapiens
1.13.11.12 bornyl vanillate IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.401 mM Homo sapiens
1.13.11.12 fenchyl caffeate IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.089 mM Homo sapiens
1.13.11.12 additional information stylosin and some similar synthetic monoterpenoids show inhibitory effects on 15-LOX. A strong positive correlation is observed between 15-LOX inhibition potential and cytotoxicity of the compounds with apoptosis being the predominant mechanism of induced cell death Homo sapiens
1.13.11.12 stylosin IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.101 mM Homo sapiens
1.13.11.31 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine
-
 Homo sapiens
1.13.11.31 adamantyl caffeate IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.074 mM Homo sapiens
1.13.11.31 bornyl vanillate IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.401 mM Homo sapiens
1.13.11.31 fenchyl caffeate IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.089 mM Homo sapiens
1.13.11.31 additional information stylosin and some similar synthetic monoterpenoids show inhibitory effects on 15-LOX. A strong positive correlation is observed between 15-LOX inhibition potential and cytotoxicity of the compounds with apoptosis being the predominant mechanism of induced cell death Homo sapiens
1.13.11.31 stylosin IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.101 mM Homo sapiens
1.13.11.33 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine
-
 Homo sapiens
1.13.11.33 adamantyl caffeate IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.074 mM Homo sapiens
1.13.11.33 bornyl vanillate IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.401 mM Homo sapiens
1.13.11.33 fenchyl caffeate IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.089 mM Homo sapiens
1.13.11.33 additional information stylosin and some similar synthetic monoterpenoids show inhibitory effects on 15-LOX. A strong positive correlation is observed between 15-LOX inhibition potential and cytotoxicity of the compounds with apoptosis being the predominant mechanism of induced cell death Homo sapiens
1.13.11.33 stylosin IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.101 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.12 Homo sapiens P16050 cf. EC 1.13.11.31, EC 1.13.11.33
-
1.13.11.31 Homo sapiens P16050 cf. EC 1.13.11.12, EC 1.13.11.33
-
1.13.11.33 Homo sapiens P16050 cf. EC 1.13.11.12, EC 1.13.11.31
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.12 fibroblast
-
 Homo sapiens
-
1.13.11.12 PC-3 cell
-
 Homo sapiens
-
1.13.11.31 fibroblast
-
 Homo sapiens
-
1.13.11.31 PC-3 cell
-
 Homo sapiens
-
1.13.11.33 fibroblast
-
 Homo sapiens
-
1.13.11.33 PC-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.12 linoleate + O2
-
 Homo sapiens (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
 ?
1.13.11.31 linoleate + O2
-
 Homo sapiens (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
 ?
1.13.11.33 linoleate + O2
-
 Homo sapiens (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.12 15-LOX-1
-
 Homo sapiens
1.13.11.12 Alox15
-
 Homo sapiens
1.13.11.31 15-LOX-1
-
 Homo sapiens
1.13.11.31 Alox15
-
 Homo sapiens
1.13.11.33 15-LOX-1
-
 Homo sapiens
1.13.11.33 Alox15
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.12 0.011
-
 pH 7.0, 25°C Homo sapiens fenchyl caffeate
1.13.11.12 0.0171
-
 pH 7.0, 25°C Homo sapiens 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine
1.13.11.12 0.0261
-
 pH 7.0, 25°C Homo sapiens adamantyl caffeate
1.13.11.12 0.0668
-
 pH 7.0, 25°C Homo sapiens stylosin
1.13.11.12 0.399
-
 pH 7.0, 25°C Homo sapiens bornyl vanillate
1.13.11.33 0.011
-
 pH 7.0, 25°C Homo sapiens fenchyl caffeate
1.13.11.33 0.0171
-
 pH 7.0, 25°C Homo sapiens 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine
1.13.11.33 0.0261
-
 pH 7.0, 25°C Homo sapiens adamantyl caffeate
1.13.11.33 0.0668
-
 pH 7.0, 25°C Homo sapiens stylosin
1.13.11.33 0.399
-
 pH 7.0, 25°C Homo sapiens bornyl vanillate