EC Number |
Inhibitors |
Structure |
---|
2.1.1.45 | 1,3-propanediphosphonic acid |
allosteric inhibitor of human thymidylate synthase; stabilizes an inactive conformer of loop 181-197. Mixed inhibitor of dUMP, uncompetitive inhibitor versus methylenetetrahydrofolate below 0.00025 mM, noncompetitive above 0.001 mM, respectively. 1,3-Propanediphosphonic acid shows positive cooperativity with antifolate inhibitor ZD9331. It leads to the formation of enzyme tetramers, but not of higher oligomers |
|
2.1.1.45 | 1-(2'-deoxyribosyl)8-azapurin-2-one 5'-monophosphate |
- |
|
2.1.1.45 | 1-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)-4-phenylthiosemicarbazide |
- |
|
2.1.1.45 | 1-(beta-D-2'-deoxyribofuranosyl)1,6-dihydro-8-azapurin-2(3H,6H)-one 5'-monophosphate |
- |
|
2.1.1.45 | 1-(beta-D-2'-Deoxyribofuranosyl)8-azapurin-2-one 5'-monophosphate |
- |
|
2.1.1.45 | 1-(beta-D-2-deoxyribofuranosyl)-4-hydroxyamino-5-bromopyrimidin-2(1H)-one 5'-monophosphate |
- |
|
2.1.1.45 | 1-(beta-D-2-deoxyribofuranosyl)-4-hydroxyamino-5-chloropyrimidin-2(1H)-one 5'-monophosphate |
- |
|
2.1.1.45 | 1-(beta-D-2-deoxyribofuranosyl)-4-hydroxyamino-5-fluoropyrimidin-2(1H)-one 5'-monophosphate |
- |
|
2.1.1.45 | 1-(beta-D-2-deoxyribofuranosyl)-4-hydroxyamino-5-hydroxymethylpyrimidin-2(1H)-one 5'-monophosphate |
- |
|
2.1.1.45 | 1-(beta-D-2-deoxyribofuranosyl)-4-hydroxyamino-5-iodopyrimidin-2(1H)-one 5'-monophosphate |
- |
|