EC Number   |
Inhibitors |
Structure |
|---|
    1.17.4.4 | (R)-warfarin |
- |
   |
| 1.17.4.4 | (S)-warfarin |
- |
|
| 1.17.4.4 | 1-hydroxyimidazopyridine |
4.0 mM, 9% inhibition, warfarin-resistant rats |
|
| 1.17.4.4 | 2,3,5,6-Tetrachloro-4-pyridinol |
2.0 mM, 45% inhibition, warfarin-resistant rats |
|
| 1.17.4.4 | 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone |
trivial name lapachol, 0.002 mM, 50% inhibition, liver microsomes from normal-strain, inhibition is fully reversible; trivial name lapachol, 50% inhibition of KO reductase activity in whole liver microsomes of warfarin-resistant rats, inhibition is fully reversible |
|
| 1.17.4.4 | ATI-5900 |
very poor VKORC1 inhibitor |
|
| 1.17.4.4 | brodifacoum |
- |
|
| 1.17.4.4 | brodifacoum |
non-competitive inhibition |
|
| 1.17.4.4 | bromadiolone |
- |
|
| 1.17.4.4 | bromadiolone |
non-competitive inhibition |
|
