EC Number   |
Inhibitors |
Structure  |
|---|
    3.6.1.23 | more |
diphosphate has no effect on activity |
 |
| 3.6.1.23 | more |
inhibitor in vivo activity against the parasite, overview |
|
| 3.6.1.23 | more |
growth inhibition potency in vitro, overview, molecular docking modeling study |
|
| 3.6.1.23 | more |
no inhibition by dTTp, dGTP, dATP, and dCTP |
|
| 3.6.1.23 | more |
the enzyme possesses a specific tryptic cleavage site Arg132-Ile133 20 A far from the active site of the enzyme, the enzyme is protected against tryptic digestion by binding alpha,beta-imino-dUTP which induces an allosteric conformational change within the central threefold channel of the homotrimer |
|
| 3.6.1.23 | more |
binding of alpha,beta-imino-dUTP does not induce allosteric conformational changes and does not protect the enzyme against tryptic digestion |
|
| 3.6.1.23 | more |
programmed cell death protein 4 downregulates dUTPase in certain cell types, overview |
|
| 3.6.1.23 | more |
fast screening for binding of potential inhibitors to the active site |
|
| 3.6.1.23 | more |
enzyme inhibitor development by high-throughput screening of triskelion libraries, a uracil-aldehyde ligand is covalently tethered to one position of a trivalent alkyloxyamine linker via an oxime linkage, and then the vacant linker positions are derivatized with a library of aldehydes, screening of triskelion oximes for inhibitory potency, overview |
|
| 3.6.1.23 | more |
computational docking of small molecules structures to the enzyme for inhibitor development, overview |
|
