EC Number |
Natural Substrates |
---|
1.14.11.69 | a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 |
- |
1.14.11.69 | dimethyl-histone 3 L-lysine 36 + 2-oxoglutarate + O2 |
enzyme Rph1 is specific for di- and trimethyl-histone 3 L-lysine36 |
1.14.11.69 | histone H3 N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 |
- |
1.14.11.69 | histone H3 N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 |
- |
1.14.11.69 | histone H3 N6-methyl-L-lysine36 + 2-oxoglutarate + O2 |
- |
1.14.11.69 | histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 |
- |
1.14.11.69 | histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 |
KDM4A demethylates H3K36me3, a modification enriched in the 3' end of active genes |
1.14.11.69 | histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 |
- |
1.14.11.69 | more |
general function of histone demethylase for histone 3 L-lysine 36 is to promote transcription elongation by antagonizing repressive L-lysine 36 methylation by Set2 methyltransferase |
1.14.11.69 | more |
HP1a and dKDM4A interact with each other and loss of HP1a leads to an increased level of histone H3K36me3 |