EC Number   |
Natural Substrates |
|---|
    1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol |
- |
| 1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol |
i.e. vitamin K 2,3-epoxide |
| 1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol |
i.e. vitamin K 2,3-epoxide, the enzyme is supposed to catalyze the reduction of the epoxide to quinone and of the quinone to vitamin K hydroquinone |
| 1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol |
i.e. vitamin K 2,3-epoxide, the enzyme initiates the vitamin K catalytic cycle, overview |
| 1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O |
- |
| 1.17.4.4 | 2,3-epoxyphylloquinone + AH2 |
- |
| 1.17.4.4 | 2,3-epoxyphylloquinone + AH2 |
the enzyme catalyzes the reduction of vitamin K 2,3-epoxide to vitamin K1, overview |
| 1.17.4.4 | 2,3-epoxyphylloquinone + AH2 |
VKOR reduces vitamin K using membrane-embedded thiols, Cys132 and Cys135, which become oxidized with concomitant VKOR inactivation. VKOR is subsequently reactivated by an unknown redox protein that might act directly on the Cys132-Cys135 residues |
| 1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol |
- |
| 1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O |
- |
