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EC Number	Application	Commentary	Reference
1.3.1.92	drug development	oral feeding of whole intact plant cells bioencapsulating the artemisinin reduces the Plasmodium falciparum parasitemia levels in challenged mice in comparison with commercial drug. The synergistic approache may facilitate low-cost production and delivery of artemisinin and other drugs through metabolic engineering of edible plants	745811
1.3.1.92	medicine	artemisinin is the main ingredient for malaria prevention. The World Health Organization recommends artemisinin combination therapies (ACT) as the first-line therapy for malaria worldwide	744971
1.3.1.92	synthesis	for enhanced artemisin production, Appropriate doses of Cd can increase the concentrations of artemisinic metabolites at a certain time point by upregulating the relative expression levels of key enzyme genes involved in artemisinin biosynthesis	744971
1.3.1.92	synthesis	production of artemisin by incubating a mixture of artemisin precursors from engineered Saccharomyces cerevisiae with a cell-free extract of Artemisia annua. Use of cold-acclimated Artemisia annua cell-free extract gives rise to considerable artemisin content up to 0.65%	717175

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Release 2023.1 (January 2023)