EC Number |
Application |
Reference |
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3.4.21.B28 | diagnostics |
diagnostic and prognostic biomarker for various types of cancer. Development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma |
753304 |
3.4.21.B28 | medicine |
expression of active seprase increases tumor growth and microvessel density |
672896 |
3.4.21.B28 | medicine |
fibroblast activation protein alpha has a high-risk correlation with the malignant level of clinical outcomes in gastric cancer patients |
753092 |
3.4.21.B28 | medicine |
protease complex consisting of seprase and dipeptidylpeptidase IV in endothelial cells that are activated to migrate and invade in the extracellular matrix in vitro and are coexpressed with the three major protease systems matrix metalloproteinase, plasminogen activator, and type II transmembrane serine protease, at the cell surface and organize as a complex at invadopodia-like protrusions |
672907 |
3.4.21.B28 | medicine |
role in the invasive and metastatic progression of gastric carcinoma, tendency towards a worse prognosis in patients whose tumors exhibit high levels of the 170000 Da seprase dimer |
676269 |
3.4.21.B28 | medicine |
selectively induced in fibrotic foci, but not in normal or emphysematous lung |
673949 |
3.4.21.B28 | medicine |
significant correlation between seprase expression and lymph node metastasis |
672887 |
3.4.21.B28 | medicine |
targeting fibroblast activation protein and cancer-associated fibroblasts in combination with radiation is capable of enhancing anti-tumor T cell infiltrate and function, but does not result in sufficient tumor clearance to extend survival |
755182 |
3.4.21.B28 | medicine |
the limited expression of the enzyme in healthy tissues together with its presence in both transformed and stromal cells suggests that it may be a candidate target for specific delivery of therapeutic agents in glioblastoma |
755628 |
3.4.21.B28 | medicine |
tumor suppressor that abrogates tumorigenicity through regulation of cell growth and survival, in vitro, FAP expression restores contact inhibition, leads to cell cylcle arrest at G0/G1 phase, increases susceptibility to stress-induced apoptosis, and leads to caspase activation |
-, 676253 |