EC Number   |
General Information |
Reference |
|---|
   3.1.1.32 | more |
the enzyme's active site is composed of a Ser-His dyad (Ser11 and His218), whereby stabilization of the imidazole is provided by the main-chain carbonyl oxygen of Ser216, a common variation of the catalytic triad in many serine hydrolases, where this carbonyl maintains the orientation of the active site histidine residue. The hydrophobic pocket and cleft for lipid binding are adjacent to the active site, and are approximately 13-15 A deep and 14-16 A long |
-, 730288 |
| 3.1.1.32 | physiological function |
by lowering the phosphatidylethanolamine content of the cell envelope, BveA increases the resistance of Brucella melitensis to polymyxin B. BveA is required for survival and replication of Brucella melitensis in macrophages and for persistent infection in mice |
-, 749593 |
| 3.1.1.32 | physiological function |
classical pancreatic lipase may fulfill in some cases additional biological functions as a phospholipase A1, PLA1, enzyme, compensating pancreatic lipase-related protein 2, PLRP2, deficiency in the digestive tract |
729305 |
| 3.1.1.32 | physiological function |
deletion of phospholipase DDL1 leads to respiratory growth defects. Introduction of COQ8, COQ9, or COQ5, which are involved in coenzyme Q synthesis, using a multicopy vector suppresses the respiratory growth defect of the DDL1 deletion mutant |
750103 |
| 3.1.1.32 | physiological function |
H-Rev107 functions principally as a Ca2+-independent PLA1/2 with a higher PLA1 activity. Transient expression of H-Rev107 in COS-7 cells does not appear to influence cell proliferation |
709425 |
| 3.1.1.32 | physiological function |
intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol |
716165 |
| 3.1.1.32 | physiological function |
is capable for activation of human basophils, relevance of Ves v 1 in hymenoptera venom allergy |
708202 |
| 3.1.1.32 | physiological function |
lysophospholipase activity in live Tryypanosoma cruzi parasites contributes to self protection against toxic compounds generated by phospholipase A1 activity |
730354 |
| 3.1.1.32 | physiological function |
mediates a specific retrograde membrane transport pathway between the endoplasmic reticulum and the Golgi complex |
709054 |
| 3.1.1.32 | physiological function |
PLA1 is the major allergen for humans in the wasp venom |
716710 |
