EC Number   |
General Information |
Reference |
|---|
   3.4.21.98 | evolution |
NS3/4A protease from HCV genotype 4a is the most prevalent genotype in Egypt |
753354 |
| 3.4.21.98 | evolution |
phylogenetic analyses of NS3 proteases sequences |
755646 |
| 3.4.21.98 | evolution |
the hepatitis C virus (HCV) is a plus stranded RNA virus belonging to the Flaviviridae family. Despite the high mutation rate of HCV, the functionally important residues are highly conserved. These include residues that form the catalytic triad (His57, Asp81, and Ser139), the S1 and S6 pocket, zinc-binding site (Cys97, Cys99, Cys145, and His149) and the substrate binding groove. The epitopes B1, B8 and B9 are over 95% conserved across six major HCV genotypes |
752918 |
| 3.4.21.98 | malfunction |
protease competent NS3 has a significant fibrogenic impact in expressing LX-2 cells when compared to protease defective NS3 or GFP control plasmids |
752415 |
| 3.4.21.98 | malfunction |
treatment of virus-infected cells with NS3 enzyme inhibitor BILN-2061 significantly increases degranulation against K-562 target cells and IFN-gamma productivity in natural killer (NK) cells of the host. The expression levels of activating NK cell receptors, such as NKp46 and NKp30, are also increased |
755143 |
| 3.4.21.98 | more |
baseline NS3 quasispecies diversity and complexity is higher in acutely infected subjects compared to a chronic hepatitis C control group. Both parameters are comparable in patients with spontaneous clearance versus treatment-induced acute hepatitis C or development of chronic hepatitis C. Longitudinal NS3 quasispecies kinetics show a trend to a decreasing diversity and complexity within 4 weeks in patients with spontaneous clearance compared to the other groups. Spontaneous clearance of acute hepatitis C, baseline clinical parameters of 82 patients with an acute hepatitis C and HIV coinfection, overview |
755646 |
| 3.4.21.98 | more |
HCV is a member of the Flaviviridae family consisting of a positive single strand RNA that encodes a polyprotein. This polyprotein is cleaved to the structural and nonstructural (NS) proteins by both host and viral proteases.4 The NS3 region is a trypsin-like serine protease that plays an essential role in viral replication and involves in processes to attenuate and evade the host cell's natural immune defense |
752949 |
| 3.4.21.98 | more |
the location of possible B- and T-cell epitopes are predicted in the HCV NS3-4A consensus sequence |
752918 |
| 3.4.21.98 | physiological function |
canine hepacivirus protease can disrupt the human innate antiviral defense signaling pathway suggesting a possible evolutionary relationship between canine hepacivirus and hepatitis C virus |
732702 |
| 3.4.21.98 | physiological function |
generation of NS3/4A/Lap/LC-1 triple transgenic mouse liver-specifically and conditionally expressing reporter luciferase Fluc, Cre recombinase and reverse tetracycline-controlled transcriptional activator. NS3/4A protein is strictly and conditionally expressed in the liver of doxycycline-induced triple transgenic mice |
732489 |
