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EC Number	Substrates	Commentary Substrates	Organism	Products	Commentary (Products)	Reversibility
1.17.98.3	formate + FAD	specific activity 5.4fold lower than for the reaction with coenzyme F420. Vmax /Km is 11fold as compared to reaction with coenzyme F420	Methanobacterium formicicum	CO2 + FADH2	-	?
1.17.98.3	formate + FMN	specific activity 9.1fold lower than for the reaction with coenzyme F420. Vmax /Km is 6.4fold as compared to reaction with coenzyme F420	Methanobacterium formicicum	CO2 + FMNH2	-	?
1.17.98.3	formate + oxidized coenzyme F420	-	Methanobacterium formicicum	CO2 + reduced coenzyme F420	-	?
1.17.98.3	formate + oxidized coenzyme F420	no activity with NAD+ or NADP*	Methanobacterium formicicum	CO2 + reduced coenzyme F420	-	?
1.17.98.3	formate + oxidized methyl viologen	-	Methanobacterium formicicum	CO2 + reduced methyl viologen	-	?
1.17.98.3	formate + oxidized methyl viologen	the enzyme is specific for the si face hydride transfer to C5 of coenzyme F420	Methanobacterium formicicum	CO2 + reduced methyl viologen	-	?
1.17.98.3	formate + oxidized coenzyme F420	-	Methanobacterium formicicum DSM 2639	CO2 + reduced coenzyme F420	-	?
1.17.98.3	formate + oxidized benzyl viologen	-	Methanobrevibacter ruminantium	CO2 + reduced benzyl viologen	-	?
1.17.98.3	formate + oxidized coenzyme F420	-	Methanobrevibacter ruminantium	CO2 + reduced coenzyme F420	-	?
1.17.98.3	formate + oxidized coenzyme F420	reduced coenzyme F420 obtained from the formate dehydrogenase can be further linked to the formation of hydrogen via the F420-dependent hydrogenase reaction	Methanobrevibacter ruminantium	CO2 + reduced coenzyme F420	-	?

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Release 2023.1 (January 2023)