EC Number |
Reference |
---|
1.14.11.29 | isoform PHD2 in complex with Mn2+, sitting drop vapor diffusion method, using 1.6 M sodium citrate/citric acid pH 6.5 |
743581 |
1.14.11.29 | L-ascorbic acid can be docked in the binding site of 2-oxoglutarate and may chelate the iron ion, D-ascorbate cannot be docked |
764238 |
1.14.11.29 | sitting-drop vapor-diffusion method, the crystal structure reveals an EF domain with two Ca2+-binding motifs inserted within the catalytic domain. A substrate-binding groove is formed between the EF domain and the conserved core of the catalytic domain |
765073 |
1.14.11.29 | structure of a truncated domain of PHD2 with MnII substituting for FeII and complexed with inhibitor 4-hydroxy-N-[(4-phenoxyphenyl)methyl]-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide reveals a binding mode involving chelation of the active site metal via nitrogen atoms of the pyrazolo and a pyrimidyl rings which adopt a coplanar conformation. The pyrazole ring of the inhibitor occupies the entrance of the active site pocket that is occupied by the CH2CO2H group of 2-oxoglutarate during catalysis |
764504 |