Search Disease/ Diagnostics

4.2.1.19

Dehydration

Crystal Structures Reveal that the Reaction Mechanism of Imidazoleglycerol-Phosphate Dehydratase Is Controlled by Switching Mn(II) Coordination.

unassigned

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4.2.1.19

Infections

Histidine biosynthesis plays a crucial role in metal homeostasis and virulence of Aspergillus fumigatus.

causal interaction
ongoing research
therapeutic application
unassigned

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4.2.1.19

Starvation

Cryptosporidium parvum: functional complementation of a parasite transcriptional coactivator CpMBF1 in yeast.

unassigned

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4.2.1.19

Starvation

Histidine biosynthesis plays a crucial role in metal homeostasis and virulence of Aspergillus fumigatus.

causal interaction
ongoing research
therapeutic application
unassigned

2
2
1
0

4.2.1.19

Tuberculosis

HisB from Mycobacterium tuberculosis: cloning, overexpression in Mycobacterium smegmatis, purification, crystallization and preliminary X-ray crystallographic analysis.

unassigned

0

4.2.1.19

Tuberculosis

Structures of native, substrate-bound and inhibited forms of Mycobacterium tuberculosis imidazoleglycerol-phosphate dehydratase.

ongoing research
unassigned

2
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4.2.1.19

Tuberculosis

Characterization of a triazole scaffold compound as an inhibitor of Mycobacterium tuberculosis imidazoleglycerol-phosphate dehydratase.

ongoing research
therapeutic application
unassigned

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