EC Number   |
Disease |
PubMed ID  |
Title of Publication |
Category |
Confidence Level |
|---|
    2.5.1.29 | Obesity |
10688662 |
The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis. |
causal interaction
unassigned |
3
0 |
| 2.5.1.29 | Neoplasms |
12694875 |
Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G2/M phase. |
causal interaction
unassigned |
1
0 |
| 2.5.1.29 | Infections |
16664817 |
Biosynthesis of the Macrocyclic Diterpene Casbene in Castor Bean (Ricinus communis L.) Seedlings : Changes in Enzyme Levels Induced by Fungal Infection and Intracellular Localization of the Pathway. |
causal interaction
unassigned |
1
0 |
| 2.5.1.29 | Leukemia |
18083912 |
Inhibition of geranylgeranyl diphosphate synthase induces apoptosis through multiple mechanisms and displays synergy with inhibition of other isoprenoid biosynthetic enzymes. |
ongoing research
therapeutic application
unassigned |
4
2
0 |
| 2.5.1.29 | Neoplasms |
19519294 |
The intermediate enzymes of isoprenoid metabolism as anticancer targets. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 2.5.1.29 | Breast Neoplasms |
20480384 |
Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
1
3
4 |
| 2.5.1.29 | Neoplasms |
20480384 |
Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
1
3
4 |
| 2.5.1.29 | Breast Neoplasms |
21335425 |
Bisphosphonates Induce Autophagy by Depleting Geranylgeranyl Diphosphate. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
1
1
1
0 |
| 2.5.1.29 | Prostatic Neoplasms |
21335425 |
Bisphosphonates Induce Autophagy by Depleting Geranylgeranyl Diphosphate. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
1
1
1
0 |
| 2.5.1.29 | Bone Resorption |
21419634 |
Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
1
1
4
0 |
