EC Number |
Protein Variants |
Reference |
---|
1.3.1.38 | F149A |
the mutant is not able to optimally position the cofactor for hydride transfer, which correlates with the 30fold decrease in kcat |
687289 |
1.3.1.38 | G225A |
upon expression in Saccharomyces cerevisiae tsc13DELTA mutant significant accumulation of fatty acids C22:0, C20:0, C18:0, C18-OH, and especially C16-OH is detected |
699263 |
1.3.1.38 | G227A |
similar to wild-type |
699263 |
1.3.1.38 | G228A |
similar to wild-type |
699263 |
1.3.1.38 | G234A |
upon expression in Saccharomyces cerevisiae tsc13DELTA mutant significant accumulation of fatty acids C22:0, C20:0, C18:0, C18-OH, and especially C16-OH is detected |
699263 |
1.3.1.38 | I231A |
upon expression in Saccharomyces cerevisiae tsc13DELTA mutant significant accumulation of fatty acids C22:0, C20:0, C18:0, C18-OH, and especially C16-OH is detected |
699263 |
1.3.1.38 | K165A |
normal expression in Escherichia coli |
657270 |
1.3.1.38 | K165Q |
normal expression in Escherichia coli |
657270 |
1.3.1.38 | more |
enzyme is able to rescue the growth of the Saccharomyces cerevisiae tsc13DELTA mutant |
699263 |
1.3.1.38 | more |
knockdown of MECR-1 resulted in life span extension |
706445 |