EC Number   |
Protein Variants |
Reference |
|---|
   3.4.21.98 | A156F |
rarely observed mutant, confers higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors |
731144 |
| 3.4.21.98 | A156G |
virus mutant variant |
752506 |
| 3.4.21.98 | A156N |
rarely observed mutant, confers higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors |
731144 |
| 3.4.21.98 | A156S |
confers resistance to SCH-503034 |
690304 |
| 3.4.21.98 | A156S |
frequently observed mutant with lower-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors |
731144 |
| 3.4.21.98 | A156S |
reduced sensitivity to BILN-2061, fully catalytically functional |
690304 |
| 3.4.21.98 | A156S |
resistant to inhibitor VX-950, sensitive to inhibitor BILN 2061 |
669395 |
| 3.4.21.98 | A156S |
virus mutant variant |
752506 |
| 3.4.21.98 | A156T |
frequently observed mutant with higher-level resistance to inhibitor telaprevir. Variant remains fully sensitive to alpha interferon, ribavirin, and HCV NS5B nucleoside and nonnucleoside polymerase inhibitors |
731144 |
| 3.4.21.98 | A156T |
NS3-protease inhibitor resistant mutation |
695249 |
