Sequence of ICMT_METAC
EC Number:2.1.1.100
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
protein-S-isoprenylcysteine O-methyltransferase
Q8TMG0
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
194
22811
Reaction
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
Other sequences found for EC No. 2.1.1.100
General information:
Sequence
0 MNENLWKICF IVMFIIWVFV RKVYGTRAMK NKSKKKVRPN FEKSLVFLNF IGMVFLPLTA
60 VFSSYLDSFN INLPDSIRLF ALIVTFLNIG LFTKIHKDLG NNWSAILEIK DGHKLVKEGI
120 YKNIRHPMYA HLWLWVITQG IILSNWVVLI FGIVAWAILY FIRVPKEEEL LIEEFGDEYI
180 EYMGKTGRLF PKVV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
46201
Galagan J.E.,Nusbaum C.,Roy A.,Endrizzi M.G.,Macdonald P.,FitzHugh W.,Calvo S.,Engels R.,Smirnov S.,Atnoor D.,Brown A.,Allen N.,Naylor J.,Stange-Thomann N.,DeArellano K.,Johnson R.,Linton L.,McEwan P.,McKernan K.,Talamas J.,Tirrell A.,Ye W.,Zimmer A.,Barber R.D.,Cann I.,Graham D.E.,Grahame D.A.,Guss A.M.,Hedderich R.,Ingram-Smith C.,Kuettner H.C.,Krzycki J.A.,Leigh J.A.,Li W.,Liu J.,Mukhopadhyay B.,Reeve J.N.,Smith K.,Springer T.A.,Umayam L.A.,White O.,White R.H.,de Macario E.C.,Ferry J.G.,Jarrell K.F.,Jing H.,Macario A.J.L.,Paulsen I.T.,Pritchett M.,Sowers K.R.,Swanson R.V.,Zinder S.H.,Lander E.,Metcalf W.W.,Birren B.
The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.
Genome Res.
12
532-542
2002
46202
Yang J.,Kulkarni K.,Manolaridis I.,Zhang Z.,Dodd R.B.,Mas-Droux C.,Barford D.
Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT.
Mol. Cell
44
997-1004
2011
