Sequence of CP51A_RAT
EC Number:1.14.14.154
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a 14alpha-formylsteroid + [reduced NADPH-hemoprotein reductase] + O2 = a DELTA14-steroid + formate + [oxidized NADPH-hemoprotein reductase] + H2O
Other sequences found for EC No. 1.14.14.154
General information:
Sequence
0 MVLLGLLQSG GSVLGQAMEQ VTGGNLLSTL LIACAFTLSL VYLFRLAVGH MVQLPAGAKS
60 PPYIYSPIPF LGHAIAFGKS PIEFLENAYE KYGPVFSFTM VGKTFTYLLG SDAAALLFNS
120 KNEDLNAEEV YGRLTTPVFG KGVAYDVPNA VFLEQKKILK SGLNIAHFKQ YVSIIEKEAK
180 EYFKSWGESG ERNVFEALSE LIILTASHCL HGKEIRSQLN EKVAQLYADL DGGFSHAAWL
240 LPGWLPLPSF RRRDRAHREI KNIFYKAIQK RRLSKEPAED ILQTLLDSTY KDGRPLTDDE
300 IAGMLIGLLL AGQHTSSTTS AWMGFFLARD KPLQDKCYLE QKTVCGEDLP PLTYEQLKDL
360 NLLDRCIKET LRLRPPIMTM MRMAKTPQTV AGYTIPPGHQ VCVSPTVNQR LKDSWVERLD
420 FNPDRYLQDN PASGEKFAYV PFGAGRHRCI GENFAYVQIK TIWSTMLRLY EFDLINGYFP
480 SVNYTTMIHT PENPVIRYKR RSK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
529810
Aoyama Y.,Funae Y.,Noshiro M.,Horiuchi T.,Yoshida Y.
Occurrence of a P450 showing high homology to yeast lanosterol 14-demethylase (P450(14DM)) in the rat liver.
Biochem. Biophys. Res. Commun.
201
1320-1326
1994
529811
Noshiro M.,Aoyama Y.,Kawamoto T.,Gotoh O.,Horiuchi T.,Yoshida Y.
Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I. Structural analyses of the gene and multiple sizes of mRNA.
J. Biochem.
122
1114-1121
1997
529812
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
529813
Sloane D.L.,So O.Y.,Leung R.,Scarafia L.E.,Saldou N.,Jarnagin K.,Swinney D.C.
Cloning and functional expression of the cDNA encoding rat lanosterol 14-alpha demethylase.
Gene
161
243-248
1995
529814
Aoyama Y.,Noshiro M.,Gotoh O.,Imaoka S.,Funae Y.,Kurosawa N.,Horiuchi T.,Yoshida Y.
Sterol 14-demethylase P450 (P45014DM*) is one of the most ancient and conserved P450 species.
J. Biochem.
119
926-933
1996
529815
Nitahara Y.,Aoyama Y.,Horiuchi T.,Noshiro M.,Yoshida Y.
Purification and characterization of rat sterol 14-demethylase P450 (CYP51) expressed in Escherichia coli.
J. Biochem.
126
927-933
1999
529816
Nitahara Y.,Kishimoto K.,Yabusaki Y.,Gotoh O.,Yoshida Y.,Horiuchi T.,Aoyama Y.
The amino acid residues affecting the activity and azole susceptibility of rat CYP51 (sterol 14-demethylase P450).
J. Biochem.
129
761-768
2001
