Sequence of PMVK_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
phosphomevalonate kinase
Q15126
Homo sapiens
192
21995
Reaction
ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MAPLGGAPRL VLLFSGKRKS GKDFVTEALQ SRLGADVCAV LRLSGPLKEQ YAQEHGLNFQ
 60 RLLDTSTYKE AFRKDMIRWG EEKRQADPGF FCRKIVEGIS QPIWLVSDTR RVSDIQWFRE
120 AYGAVTQTVR VVALEQSRQQ RGWVFTPGVD DAESECGLDN FGDFDWVIEN HGVEQRLEEQ
180 LENLIEFIRS RL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
71508
Chambliss K.L.,Slaughter C.A.,Schreiner R.,Hoffmann G.F.,Gibson K.M.
Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence.
J. Biol. Chem.
271
17330-17334
1996
71510
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
71511
Olivier L.M.,Chambliss K.L.,Gibson K.M.,Krisans S.K.
Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting.
J. Lipid Res.
40
672-679
1999
71512
Hinson D.D.,Chambliss K.L.,Toth M.J.,Tanaka R.D.,Gibson K.M.
Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.
J. Lipid Res.
38
2216-2223
1997
71513
Hogenboom S.,Tuyp J.J.,Espeel M.,Koster J.,Wanders R.J.,Waterham H.R.
Phosphomevalonate kinase is a cytosolic protein in humans.
J. Lipid Res.
45
697-705
2004
71514
Herdendorf T.J.,Miziorko H.M.
Phosphomevalonate kinase: functional investigation of the recombinant human enzyme.
Biochemistry
45
3235-3242
2006
71515
Herdendorf T.J.,Miziorko H.M.
Functional evaluation of conserved basic residues in human phosphomevalonate kinase.
Biochemistry
46
11780-11788
2007
71516
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
71517
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
109
12449-12454
2012
71518
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
71519
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
71520
Chang Q.,Yan X.-X.,Gu S.-Y.,Liu J.-F.,Liang D.-C.
Crystal structure of human phosphomevalonate kinase at 1.8 A resolution.
Proteins
73
254-258
2008
71521
Zhang Z.,Li C.,Wu F.,Ma R.,Luan J.,Yang F.,Liu W.,Wang L.,Zhang S.,Liu Y.,Gu J.,Hua W.,Fan M.,Peng H.,Meng X.,Song N.,Bi X.,Gu C.,Zhang Z.,Huang Q.,Chen L.,Xiang L.,Xu J.,Zheng Z.,Jiang Z.
Genomic variations of the mevalonate pathway in porokeratosis.
Elife
4
0-0
2015
71522
Wang J.,Liu Y.,Liu F.,Huang C.,Han S.,Lv Y.,Liu C.J.,Zhang S.,Qin Y.,Ling L.,Gao M.,Yu S.,Li C.,Huang M.,Liao S.,Hu X.,Lu Z.,Liu X.,Jiang T.,Tang Z.,Zhang H.,Guo A.Y.,Liu M.
Loss-of-function mutation in PMVK causes autosomal dominant disseminated superficial porokeratosis.
Sci. Rep.
6
24226-24226
2016