Sequence of CP51_CANAL

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
sterol 14alpha-demethylase
P10613
Candida albicans (strain SC5314 / ATCC MYA-2876)
528
60675
Reaction
a 14alpha-formylsteroid + [reduced NADPH-hemoprotein reductase] + O2 = a DELTA14-steroid + formate + [oxidized NADPH-hemoprotein reductase] + H2O
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MAIVETVIDG INYFLSLSVT QQISILLGVP FVYNLVWQYL YSLRKDRAPL VFYWIPWFGS
 60 AASYGQQPYE FFESCRQKYG DVFSFMLLGK IMTVYLGPKG HEFVFNAKLS DVSAEDAYKH
120 LTTPVFGKGV IYDCPNSRLM EQKKFAKFAL TTDSFKRYVP KIREEILNYF VTDESFKLKE
180 KTHGVANVMK TQPEITIFTA SRSLFGDEMR RIFDRSFAQL YSDLDKGFTP INFVFPNLPL
240 PHYWRRDAAQ KKISATYMKE IKSRRERGDI DPNRDLIDSL LIHSTYKDGV KMTDQEIANL
300 LIGILMGGQH TSASTSAWFL LHLGEKPHLQ DVIYQEVVEL LKEKGGDLND LTYEDLQKLP
360 SVNNTIKETL RMHMPLHSIF RKVTNPLRIP ETNYIVPKGH YVLVSPGYAH TSERYFDNPE
420 DFDPTRWDTA AAKANSVSFN SSDEVDYGFG KVSKGVSSPY LPFGGGRHRC IGEQFAYVQL
480 GTILTTFVYN LRWTIDGYKV PDPDYSSMVV LPTEPAEIIW EKRETCMF
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
18778
Lai M.H.,Kirsch D.R.
Nucleotide sequence of cytochrome P450 L1A1 (lanosterol 14 alpha-demethylase) from Candida albicans.
Nucleic Acids Res.
17
804-804
1989
18780
Jones T.,Federspiel N.A.,Chibana H.,Dungan J.,Kalman S.,Magee B.B.,Newport G.,Thorstenson Y.R.,Agabian N.,Magee P.T.,Davis R.W.,Scherer S.
The diploid genome sequence of Candida albicans.
Proc. Natl. Acad. Sci. U.S.A.
101
7329-7334
2004
18781
van het Hoog M.,Rast T.J.,Martchenko M.,Grindle S.,Dignard D.,Hogues H.,Cuomo C.,Berriman M.,Scherer S.,Magee B.B.,Whiteway M.,Chibana H.,Nantel A.,Magee P.T.
Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.
Genome Biol.
8
0-0
2007
18782
Muzzey D.,Schwartz K.,Weissman J.S.,Sherlock G.
Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.
Genome Biol.
14
0-0
2013
18783
White T.C.
The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14-alpha demethylase in Candida albicans.
Antimicrob. Agents Chemother.
41
1488-1494
1997
18784
Boscott P.E.,Grant G.H.
Modeling cytochrome P450 14-alpha demethylase (Candida albicans) from P450cam.
J. Mol. Graph.
12
185-192
1994
18785
Loffler J.,Kelly S.L.,Hebart H.,Schumacher U.,Lass-Florl C.,Einsele H.
Molecular analysis of cyp51 from fluconazole-resistant Candida albicans strains.
FEMS Microbiol. Lett.
151
263-268
1997