Sequence of PSB8_HUMAN
EC Number:3.4.25.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
cleavage of peptide bonds with very broad specificity
Other sequences found for EC No. 3.4.25.1
General information:
Sequence
0 MALLDVCGAP RGQRPESALP VAGSGRRSDP GHYSFSMRSP ELALPRGMQP TEFFQSLGGD
60 GERNVQIEMA HGTTTLAFKF QHGVIAAVDS RASAGSYISA LRVNKVIEIN PYLLGTMSGC
120 AADCQYWERL LAKECRLYYL RNGERISVSA ASKLLSNMMC QYRGMGLSMG SMICGWDKKG
180 PGLYYVDEHG TRLSGNMFST GSGNTYAYGV MDSGYRPNLS PEEAYDLGRR AIAYATHRDS
240 YSGGVVNMYH MKEDGWVKVE STDVSDLLHQ YREANQ
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
210067
Glynne R.,Kerr L.A.,Mockridge I.,Beck S.,Kelly A.,Trowsdale J.
The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing.
Eur. J. Immunol.
23
860-866
1993
210068
Beck S.,Kelly A.,Radley E.,Khurshid F.,Alderton R.P.,Trowsdale J.
DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing.
J. Mol. Biol.
228
433-441
1992
210069
Glynne R.,Powis S.H.,Beck S.,Kelly A.,Kerr L.A.,Trowsdale J.
A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC.
Nature
353
357-360
1991
210070
Fruh K.,Yang Y.,Arnold D.,Chambers J.,Wu L.,Waters J.B.,Spies T.,Peterson P.A.
Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits.
J. Biol. Chem.
267
22131-22140
1992
210071
Meinhardt T.,Graf U.,Hammerling G.J.
Different genomic structure of mouse and human Lmp7 genes: characterization of MHC-encoded proteasome genes.
Immunogenetics
38
373-379
1993
210072
Beck S.,Abdulla S.,Alderton R.P.,Glynne R.J.,Gut I.G.,Hosking L.K.,Jackson A.,Kelly A.,Newell W.R.,Sanseau P.,Radley E.,Thorpe K.L.,Trowsdale J.
Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.
J. Mol. Biol.
255
1-13
1996
210074
Mungall A.J.,Palmer S.A.,Sims S.K.,Edwards C.A.,Ashurst J.L.,Wilming L.,Jones M.C.,Horton R.,Hunt S.E.,Scott C.E.,Gilbert J.G.R.,Clamp M.E.,Bethel G.,Milne S.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Andrews T.D.,Ashwell R.I.S.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Barker D.J.,Barlow K.F.,Bates K.,Beare D.M.,Beasley H.,Beasley O.,Bird C.P.,Blakey S.E.,Bray-Allen S.,Brook J.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Carder C.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clark G.,Clee C.M.,Clegg S.,Cobley V.,Collier R.E.,Collins J.E.,Colman L.K.,Corby N.R.,Coville G.J.,Culley K.M.,Dhami P.,Davies J.,Dunn M.,Earthrowl M.E.,Ellington A.E.,Evans K.A.,Faulkner L.,Francis M.D.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Ghori M.J.,Gilby L.M.,Gillson C.J.,Glithero R.J.,Grafham D.V.,Grant M.,Gribble S.,Griffiths C.,Griffiths M.N.D.,Hall R.,Halls K.S.,Hammond S.,Harley J.L.,Hart E.A.,Heath P.D.,Heathcott R.,Holmes S.J.,Howden P.J.,Howe K.L.,Howell G.R.,Huckle E.,Humphray S.J.,Humphries M.D.,Hunt A.R.,Johnson C.M.,Joy A.A.,Kay M.,Keenan S.J.,Kimberley A.M.,King A.,Laird G.K.,Langford C.,Lawlor S.,Leongamornlert D.A.,Leversha M.,Lloyd C.R.,Lloyd D.M.,Loveland J.E.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,Maslen G.L.,Matthews L.,McCann O.T.,McLaren S.J.,McLay K.,McMurray A.,Moore M.J.F.,Mullikin J.C.,Niblett D.,Nickerson T.,Novik K.L.,Oliver K.,Overton-Larty E.K.,Parker A.,Patel R.,Pearce A.V.,Peck A.I.,Phillimore B.J.C.T.,Phillips S.,Plumb R.W.,Porter K.M.,Ramsey Y.,Ranby S.A.,Rice C.M.,Ross M.T.,Searle S.M.,Sehra H.K.,Sheridan E.,Skuce C.D.,Smith S.,Smith M.,Spraggon L.,Squares S.L.,Steward C.A.,Sycamore N.,Tamlyn-Hall G.,Tester J.,Theaker A.J.,Thomas D.W.,Thorpe A.,Tracey A.,Tromans A.,Tubby B.,Wall M.,Wallis J.M.,West A.P.,White S.S.,Whitehead S.L.,Whittaker H.,Wild A.,Willey D.J.,Wilmer T.E.,Wood J.M.,Wray P.W.,Wyatt J.C.,Young L.,Younger R.M.,Bentley D.R.,Coulson A.,Durbin R.M.,Hubbard T.,Sulston J.E.,Dunham I.,Rogers J.,Beck S.
The DNA sequence and analysis of human chromosome 6.
Nature
425
805-811
2003
210076
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
210077
Kim T.G.,Lee Y.H.,Choi H.B.,Han H.
Two newly discovered alleles of major histocompatibility complex-encoded LMP7 in Korean populations.
Hum. Immunol.
46
61-64
1996
210078
Akiyama K.,Kagawa S.,Tamura T.,Shimbara N.,Takashina M.,Kristensen P.,Hendil K.B.,Tanaka K.,Ichihara A.
Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-gamma for acquirement of the functional diversity responsible for antigen processing.
FEBS Lett.
343
85-88
1994
210079
Gaczynska M.,Goldberg A.L.,Tanaka K.,Hendil K.B.,Rock K.L.
Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-gamma-induced subunits LMP2 and LMP7.
J. Biol. Chem.
271
17275-17280
1996
210080
Hallermalm K.,Seki K.,Wei C.,Castelli C.,Rivoltini L.,Kiessling R.,Levitskaya J.
Tumor necrosis factor-alpha induces coordinated changes in major histocompatibility class I presentation pathway, resulting in increased stability of class I complexes at the cell surface.
Blood
98
1108-1115
2001
210081
Li J.,Schuler-Thurner B.,Schuler G.,Huber C.,Seliger B.
Bipartite regulation of different components of the MHC class I antigen-processing machinery during dendritic cell maturation.
Int. Immunol.
13
1515-1523
2001
210082
Apcher G.S.,Heink S.,Zantopf D.,Kloetzel P.-M.,Schmid H.-P.,Mayer R.J.,Krueger E.
Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.
FEBS Lett.
553
200-204
2003
210083
Raghavendra Prasad H.S.,Qi Z.,Srinivasan K.N.,Gopalakrishnakone P.
Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach.
Toxicon
44
597-608
2004
210084
Namiki S.,Nakamura T.,Oshima S.,Yamazaki M.,Sekine Y.,Tsuchiya K.,Okamoto R.,Kanai T.,Watanabe M.
IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.
FEBS Lett.
579
2781-2787
2005
210085
Begley G.S.,Horvath A.R.,Taylor J.C.,Higgins C.F.
Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.
Mol. Immunol.
42
137-141
2005
210086
Heink S.,Ludwig D.,Kloetzel P.-M.,Krueger E.
IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response.
Proc. Natl. Acad. Sci. U.S.A.
102
9241-9246
2005
210087
Heink S.,Fricke B.,Ludwig D.,Kloetzel P.M.,Krueger E.
Tumor cell lines expressing the proteasome subunit isoform LMP7E1 exhibit immunoproteasome deficiency.
Cancer Res.
66
649-652
2006
210088
Callahan M.K.,Wohlfert E.A.,Menoret A.,Srivastava P.K.
Heat shock up-regulates lmp2 and lmp7 and enhances presentation of immunoproteasome-dependent epitopes.
J. Immunol.
177
8393-8399
2006
210089
Wu F.,Dassopoulos T.,Cope L.,Maitra A.,Brant S.R.,Harris M.L.,Bayless T.M.,Parmigiani G.,Chakravarti S.
Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis.
Inflamm. Bowel Dis.
13
807-821
2007
210090
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
210091
Yang Z.,Gagarin D.,St Laurent G. III,Hammell N.,Toma I.,Hu C.A.,Iwasa A.,McCaffrey T.A.
Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon-inducible immunoproteasome.
Arterioscler. Thromb. Vasc. Biol.
29
1213-1219
2009
210092
Eisemann J.,Prechtel A.T.,Muehl-Zuerbes P.,Steinkasserer A.,Kummer M.
Herpes simplex virus type I infection of mature dendritic cells leads to reduced LMP7-mRNA-expression levels.
Immunobiology
214
861-867
2009
210093
Muchamuel T.,Basler M.,Aujay M.A.,Suzuki E.,Kalim K.W.,Lauer C.,Sylvain C.,Ring E.R.,Shields J.,Jiang J.,Shwonek P.,Parlati F.,Demo S.D.,Bennett M.K.,Kirk C.J.,Groettrup M.
A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.
Nat. Med.
15
781-787
2009
210094
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
210095
Kitamura A.,Maekawa Y.,Uehara H.,Izumi K.,Kawachi I.,Nishizawa M.,Toyoshima Y.,Takahashi H.,Standley D.M.,Tanaka K.,Hamazaki J.,Murata S.,Obara K.,Toyoshima I.,Yasutomo K.
A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans.
J. Clin. Invest.
121
4150-4160
2011
210096
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
210097
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
210098
Ebstein F.,Textoris-Taube K.,Keller C.,Golnik R.,Vigneron N.,Van den Eynde B.J.,Schuler-Thurner B.,Schadendorf D.,Lorenz F.K.,Uckert W.,Urban S.,Lehmann A.,Albrecht-Koepke N.,Janek K.,Henklein P.,Niewienda A.,Kloetzel P.M.,Mishto M.
Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes.
Sci. Rep.
6
24032-24032
2016
210099
Agarwal A.K.,Xing C.,DeMartino G.N.,Mizrachi D.,Hernandez M.D.,Sousa A.B.,Martinez de Villarreal L.,dos Santos H.G.,Garg A.
PSMB8 encoding the beta5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome.
Am. J. Hum. Genet.
87
866-872
2010
210100
Liu Y.,Ramot Y.,Torrelo A.,Paller A.S.,Si N.,Babay S.,Kim P.W.,Sheikh A.,Lee C.C.,Chen Y.,Vera A.,Zhang X.,Goldbach-Mansky R.,Zlotogorski A.
Mutations in proteasome subunit beta type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity.
Arthritis Rheum.
64
895-907
2012
210101
Arima K.,Kinoshita A.,Mishima H.,Kanazawa N.,Kaneko T.,Mizushima T.,Ichinose K.,Nakamura H.,Tsujino A.,Kawakami A.,Matsunaka M.,Kasagi S.,Kawano S.,Kumagai S.,Ohmura K.,Mimori T.,Hirano M.,Ueno S.,Tanaka K.,Tanaka M.,Toyoshima I.,Sugino H.,Yamakawa A.,Tanaka K.,Niikawa N.,Furukawa F.,Murata S.,Eguchi K.,Ida H.,Yoshiura K.
Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome.
Proc. Natl. Acad. Sci. U.S.A.
108
14914-14919
2011
210102
Brehm A.,Liu Y.,Sheikh A.,Marrero B.,Omoyinmi E.,Zhou Q.,Montealegre G.,Biancotto A.,Reinhardt A.,Almeida de Jesus A.,Pelletier M.,Tsai W.L.,Remmers E.F.,Kardava L.,Hill S.,Kim H.,Lachmann H.J.,Megarbane A.,Chae J.J.,Brady J.,Castillo R.D.,Brown D.,Casano A.V.,Gao L.,Chapelle D.,Huang Y.,Stone D.,Chen Y.,Sotzny F.,Lee C.C.,Kastner D.L.,Torrelo A.,Zlotogorski A.,Moir S.,Gadina M.,McCoy P.,Wesley R.,Rother K.,Hildebrand P.W.,Brogan P.,Krueger E.,Aksentijevich I.,Goldbach-Mansky R.
Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production.
J. Clin. Invest.
125
4196-4211
2015
210103
Cavalcante M.P.,Brunelli J.B.,Miranda C.C.,Novak G.V.,Malle L.,Aikawa N.E.,Jesus A.A.,Silva C.A.
CANDLE syndrome: chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature-a rare case with a novel mutation.
Eur. J. Pediatr.
175
735-740
2016
