Sequence of CP46A_MOUSE

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
cholesterol 24-hydroxylase
Q9WVK8
Mus musculus
500
56814
Reaction
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MSPGLLLLGS AVLLAFGLCC TFVHRARSRY EHIPGPPRPS FLLGHLPYFW KKDEDCGRVL
 60 QDVFLDWAKK YGPVVRVNVF YKTSVIVTSP ESVKKFLMST KYNKDSKMYR ALQTVFGERL
120 FGQGLVSECD YGRWYKQRKV MDLAFSRSSL VSLMETFNEK AEQLVEILEA KADGQTPVSM
180 QDMLTCATID ILAKAAFGME TSMLLGAQKP LSQAVKVMLE GISASRNTLA KFMPGKRKQL
240 REIRESIRLL RQVGKDWVQR RREALKRGED MPADILTQIL KAEEGAQDDE VLLDNFVTFF
300 IAGHETSANH LAFTVMELSR QPEIVARLQA EVDEVVGSKR HLDYEDLGRL QYLSQVLKES
360 LRLYPPAWGT FRLLEEETLI DGVRVPGNTP LLFSTYVMGR MDTYFEDPLT FNPDRFGPGA
420 PKPRFTYFPF SLGHRSCIGQ QFAQMEVKVV MAKLLQRIEF RLVPGQRFGL QEQATLKPLD
480 PVLCTLRPRG WQPAPPPPPC
Download this sequence
in fasta format
Download all sequences for 1.14.14.25
in fasta format
in csv (Excel, OpenOffice) format
Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
269178
Lund E.G.,Guileyardo J.M.,Russell D.W.
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.
Proc. Natl. Acad. Sci. U.S.A.
96
7238-7243
1999
269179
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
269180
Kotti T.J.,Ramirez D.M.,Pfeiffer B.E.,Huber K.M.,Russell D.W.
Brain cholesterol turnover required for geranylgeraniol production and learning in mice.
Proc. Natl. Acad. Sci. U.S.A.
103
3869-3874
2006
269181
Ramirez D.M.,Andersson S.,Russell D.W.
Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain.
J. Comp. Neurol.
507
1676-1693
2008
269182
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
269183
Mast N.,Anderson K.W.,Lin J.B.,Li Y.,Turko I.V.,Tatsuoka C.,Bjorkhem I.,Pikuleva I.A.
Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum.
J. Biol. Chem.
292
4913-4924
2017