Sequence of SAHH_HUMAN
EC Number:3.13.2.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine
Other sequences found for EC No. 3.13.2.1
General information:
Sequence
0 MSDKLPYKVA DIGLAAWGRK ALDIAENEMP GLMRMRERYS ASKPLKGARI AGCLHMTVET
60 AVLIETLVTL GAEVQWSSCN IFSTQDHAAA AIAKAGIPVY AWKGETDEEY LWCIEQTLYF
120 KDGPLNMILD DGGDLTNLIH TKYPQLLPGI RGISEETTTG VHNLYKMMAN GILKVPAINV
180 NDSVTKSKFD NLYGCRESLI DGIKRATDVM IAGKVAVVAG YGDVGKGCAQ ALRGFGARVI
240 ITEIDPINAL QAAMEGYEVT TMDEACQEGN IFVTTTGCID IILGRHFEQM KDDAIVCNIG
300 HFDVEIDVKW LNENAVEKVN IKPQVDRYRL KNGRRIILLA EGRLVNLGCA MGHPSFVMSN
360 SFTNQVMAQI ELWTHPDKYP VGVHFLPKKL DEAVAEAHLG KLNVKLTKLT EKQAQYLGMS
420 CDGPFKPDHY RY
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
356077
Coulter-Karis D.E.,Hershfield M.S.
Sequence of full length cDNA for human S-adenosylhomocysteine hydrolase.
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1989
356079
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
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Nat. Genet.
36
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2004
356080
Deloukas P.,Matthews L.H.,Ashurst J.L.,Burton J.,Gilbert J.G.R.,Jones M.,Stavrides G.,Almeida J.P.,Babbage A.K.,Bagguley C.L.,Bailey J.,Barlow K.F.,Bates K.N.,Beard L.M.,Beare D.M.,Beasley O.P.,Bird C.P.,Blakey S.E.,Bridgeman A.M.,Brown A.J.,Buck D.,Burrill W.D.,Butler A.P.,Carder C.,Carter N.P.,Chapman J.C.,Clamp M.,Clark G.,Clark L.N.,Clark S.Y.,Clee C.M.,Clegg S.,Cobley V.E.,Collier R.E.,Connor R.E.,Corby N.R.,Coulson A.,Coville G.J.,Deadman R.,Dhami P.D.,Dunn M.,Ellington A.G.,Frankland J.A.,Fraser A.,French L.,Garner P.,Grafham D.V.,Griffiths C.,Griffiths M.N.D.,Gwilliam R.,Hall R.E.,Hammond S.,Harley J.L.,Heath P.D.,Ho S.,Holden J.L.,Howden P.J.,Huckle E.,Hunt A.R.,Hunt S.E.,Jekosch K.,Johnson C.M.,Johnson D.,Kay M.P.,Kimberley A.M.,King A.,Knights A.,Laird G.K.,Lawlor S.,Lehvaeslaiho M.H.,Leversha M.A.,Lloyd C.,Lloyd D.M.,Lovell J.D.,Marsh V.L.,Martin S.L.,McConnachie L.J.,McLay K.,McMurray A.A.,Milne S.A.,Mistry D.,Moore M.J.F.,Mullikin J.C.,Nickerson T.,Oliver K.,Parker A.,Patel R.,Pearce T.A.V.,Peck A.I.,Phillimore B.J.C.T.,Prathalingam S.R.,Plumb R.W.,Ramsay H.,Rice C.M.,Ross M.T.,Scott C.E.,Sehra H.K.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.L.,Soderlund C.,Steward C.A.,Sulston J.E.,Swann R.M.,Sycamore N.,Taylor R.,Tee L.,Thomas D.W.,Thorpe A.,Tracey A.,Tromans A.C.,Vaudin M.,Wall M.,Wallis J.M.,Whitehead S.L.,Whittaker P.,Willey D.L.,Williams L.,Williams S.A.,Wilming L.,Wray P.W.,Hubbard T.,Durbin R.M.,Bentley D.R.,Beck S.,Rogers J.
The DNA sequence and comparative analysis of human chromosome 20.
Nature
414
865-871
2001
356082
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
356083
Gupta R.A.,Yuan C.-S.,Ault-Riche D.B.,Borchardt R.T.
Limited proteolysis of S-adenosylhomocysteine hydrolase: implications for the three-dimensional structure.
Arch. Biochem. Biophys.
319
365-371
1995
356085
Arredondo-Vega F.X.,Charlton J.A.,Edwards Y.H.,Hopkinson D.A.,Whitehouse D.B.
Isozyme and DNA analysis of human S-adenosyl-L-homocysteine hydrolase (AHCY).
Ann. Hum. Genet.
53
157-167
1989
356086
Yuan C.S.,Borchardt R.T.
Photoaffinity labeling of human placental S-adenosylhomocysteine hydrolase with [2-3H]8-azido-adenosine.
J. Biol. Chem.
270
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1995
356087
Yin D.,Yang X.,Hu Y.,Kuczera K.,Schowen R.L.,Borchardt R.T.,Squier T.C.
Substrate binding stabilizes S-adenosylhomocysteine hydrolase in a closed conformation.
Biochemistry
39
9811-9818
2000
356088
Chi A.,Valencia J.C.,Hu Z.-Z.,Watabe H.,Yamaguchi H.,Mangini N.J.,Huang H.,Canfield V.A.,Cheng K.C.,Yang F.,Abe R.,Yamagishi S.,Shabanowitz J.,Hearing V.J.,Wu C.,Appella E.,Hunt D.F.
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
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5
3135-3144
2006
356089
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
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5
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2011
356090
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
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12
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2013
356091
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
356092
Huang H.,Luo Z.,Qi S.,Huang J.,Xu P.,Wang X.,Gao L.,Li F.,Wang J.,Zhao W.,Gu W.,Chen Z.,Dai L.,Dai J.,Zhao Y.
Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.
Cell Res.
28
111-125
2018
356093
Turner M.A.,Yuan C.S.,Borchardt R.T.,Hershfield M.S.,Smith G.D.,Howell P.L.
Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength.
Nat. Struct. Biol.
5
369-376
1998
356094
Yang X.,Hu Y.,Yin D.H.,Turner M.A.,Wang M.,Borchardt R.T.,Howell P.L.,Kuczera K.,Schowen R.L.
Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions.
Biochemistry
42
1900-1909
2003
356095
Gellekink H.,den Heijer M.,Kluijtmans L.A.,Blom H.J.
Effect of genetic variation in the human S-adenosylhomocysteine hydrolase gene on total homocysteine concentrations and risk of recurrent venous thrombosis.
Eur. J. Hum. Genet.
12
942-948
2004
356096
Baric I.,Fumic K.,Glenn B.,Cuk M.,Schulze A.,Finkelstein J.D.,James S.J.,Mejaski-Bosnjak V.,Pazanin L.,Pogribny I.P.,Rados M.,Sarnavka V.,Scukanec-Spoljar M.,Allen R.H.,Stabler S.,Uzelac L.,Vugrek O.,Wagner C.,Zeisel S.,Mudd S.H.
S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism.
Proc. Natl. Acad. Sci. U.S.A.
101
4234-4239
2004
356097
Buist N.R.,Glenn B.,Vugrek O.,Wagner C.,Stabler S.,Allen R.H.,Pogribny I.,Schulze A.,Zeisel S.H.,Baric I.,Mudd S.H.
S-adenosylhomocysteine hydrolase deficiency in a 26-year-old man.
J. Inherit. Metab. Dis.
29
538-545
2006
356098
Vugrek O.,Beluzic R.,Nakic N.,Mudd S.H.
S-adenosylhomocysteine hydrolase (AHCY) deficiency: two novel mutations with lethal outcome.
Hum. Mutat.
30
0-0
2009
356099
Grubbs R.,Vugrek O.,Deisch J.,Wagner C.,Stabler S.,Allen R.,Baric I.,Rados M.,Mudd S.H.
S-adenosylhomocysteine hydrolase deficiency: two siblings with fetal hydrops and fatal outcomes.
J. Inherit. Metab. Dis.
33
705-713
2010
