1.13.11.20: cysteine dioxygenase
This is an abbreviated version!
For detailed information about cysteine dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.20
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1.13.11.20
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taurine
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sulfinic
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non-heme
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hypotaurine
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cysteinesulfinate
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cysteamine
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cystathionine
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3-mercaptopropionate
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cys-tyr
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taut
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adenosyltransferase
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desulfhydration
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2-his-1-carboxylate
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gamma-lyase
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cupins
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2-aminoethanethiol
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medicine
- 1.13.11.20
- taurine
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sulfinic
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non-heme
- hypotaurine
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cysteinesulfinate
- cysteamine
- cystathionine
- 3-mercaptopropionate
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cys-tyr
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taut
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adenosyltransferase
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desulfhydration
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2-his-1-carboxylate
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gamma-lyase
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cupins
- 2-aminoethanethiol
- medicine
Reaction
Synonyms
3-mercaptopropionate dioxygenase, 3MDO, ADO, Arg-type CDO, BsCDO, CDO, CDO1, CDO2, CdoA, CdoB, cysteine dioxygenase, cysteine dioxygenase type 1, cysteine oxidase, Fe(II) cysteine dioxygenase, H16_A1614, H16_B1863, NP_251292, oxygenase, cysteine di-, PA2602, PCO1, PCO4
ECTree
1.13.11.20 cysteine dioxygenaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 1.13.11.20 - cysteine dioxygenase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
alpha-ketoglutarate
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alpha-ketoglutarate inhibits cysteine dioxygenase with 50% inhibition at 6.8 mM
aspartic acid
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aspartic acid decreases enzyme activity to 50% at a concentration of 1.5 mM. Replacing the sulfydryl by the uncharged hydroxyl group of serine does not affect enzyme activity.
CdCl2
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cells transfected with wild-type enzyme show an enhanced sensitivity to CdCl2 that is limited to cells cultured in medium with cysteine levels of 0.1 and 0.3mM
cytokine tumor necrosis factor-alpha
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also TNF-alpha, down-regulation observed in hepatic and brain cells
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D-cysteinesulfinate
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34.4% inhibition in hepatocytes from rats fed a low casein diet, 71.8% inhibition in hepatocytes from rats fed a moderate casein diet, 64.4% inhibition in hepatocytes from rats fed a high casein diet
ethylxanthate
0.002 mM, 110% of initial activity, 0.004 mM, 89% of initial activity
L-cysteine
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concentrations of cysteine of 2 mM and above are inhibitory in assays of purified cysteine dioxygenase
Mercaptopropionic acid
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mercaptopropionic acid at a concentration of 1.2 mM inhibits cysteine dioxygenase activity by 50%
Neocuproine
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with protein-A: 18% inhibition at 0.1 mM, without protein-A: slight activation at 0.1 mM
S-carboxymethylcysteine
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S-carboxymethylcysteine exhibits 50% inhibition at a concentration of 2.3 mM
transforming growth factor-beta
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also TGF-beta, down-regulation observed in hepatic and brain cells
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2,2'-dipyridyl
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non preincubated protein-B: 76% inhibition at 1 mM, with cysteine preincubated protein-B: no inhibition
2,2'-dipyridyl
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with protein-A: 100% inhibition at 0.1 mM, without protein-A: 58% inhibition at 0.1 mM
2-amino-ethanethiol
1 x the Km for cysteine = -2.5% inhibition, 10 x the Km for cysteine = 20% inhibition
2-amino-ethanethiol
YubC: 1 x the Km for cysteine = 12% inhibition, 10 x the Km for cysteine = 19% inhibition
2-amino-ethanethiol
1 x the Km for cysteine = 8.7% inhibition, 10 x the Km for cysteine = 30% inhibition
2-amino-ethanethiol
SCO3035: 1 x the Km for cysteine = 7.5% inhibition, 10 x the Km for cysteine = 27% inhibition; SCO5772: 1 x the Km for cysteine = 0.9% inhibition, 10 x the Km for cysteine = 28% inhibition
2-sulfanyl-ethanol
1 x the Km for cysteine = 4.8% inhibition, 10 x the Km for cysteine = 11% inhibition
2-sulfanyl-ethanol
YubC: 1 x the Km for cysteine = -0.7% inhibition, 10 x the Km for cysteine = 6.6% inhibition
2-sulfanyl-ethanol
1 x the Km for cysteine = 5.9% inhibition, 10 x the Km for cysteine = 13% inhibition
2-sulfanyl-ethanol
SCO3035: 1 x the Km for cysteine = 8.6% inhibition, 10 x the Km for cysteine = 15% inhibition; SCO5772: 1 x the Km for cysteine = 2.6% inhibition, 10 x the Km for cysteine = 13% inhibition
3-sulfanyl-propionic acid
1 x the Km for cysteine = 3.2% inhibition, 10 x the Km for cysteine = 12% inhibition
3-sulfanyl-propionic acid
YubC: 1 x the Km for cysteine = 4.7% inhibition, 10 x the Km for cysteine = 11% inhibition
3-sulfanyl-propionic acid
1 x the Km for cysteine = 4.9% inhibition, 10 x the Km for cysteine = 26% inhibition
3-sulfanyl-propionic acid
SCO3035: 1 x the Km for cysteine = 2.9% inhibition, 10 x the Km for cysteine = 11% inhibition; SCO5772: 1 x the Km for cysteine = 5.6% inhibition, 10 x the Km for cysteine = 16% inhibition
8-hydroxyquinoline
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with protein-A: 100% inhibition at 0.1 mM, without protein-A: 99% inhibition at 0.1 mM
azide
competitive inhibitor, binding structure, overview. Azide does not bind in the enzyme crystal as a superoxide mimic
Bathocuproine sulfonate
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80% inhibition at 0.01 mM, 83% inhibition at 0.1 mM
Bathocuproine sulfonate
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with protein-A: 5% inhibition at 0.1 mM, without protein-A: 38% inhibition at 0.1 mM
bathophenanthroline sulfonate
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68% inhibition at 0.01 mM, 100% inhibition at 0.1 mM
bathophenanthroline sulfonate
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with protein-A: 88% inhibition, without protein-A: 100% inhibition
DL-propargylglycine
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45.5% inhibition in hepatocytes from rats fed a high casein diet
DL-propargylglycine
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reduces the enzyme activity in methionine-supplemented medium to the basal level, does not reduce the enzyme activity in cysteine-supplemented medium, no effect in hepatocytes cultured in basal medium
EDTA
0.05 mM, 80% of initial activity, 0.1 mM, 61% of initial activity; 40% inhibition at 0.1 mM, 65% inhibition at 0.2 mM; complete inhibition at 0.05 mM
EDTA
an EDTA:cysteine dioxygenase molar ratio of about 1000:1 abolish`s cysteine oxidase activity
EDTA
enzyme activity is completely abolished at EDTA concentrations above 0.5 mM
EDTA
higher kcat and lower Km value, when the enzyme is expressed in medium containing extra iron and purified in buffers lacking EDTA.
EDTA
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non preincubated protein-B: 91% inhibition at 1 mM, with cysteine preincubated protein-B: 51% inhibition at 1 mM
EDTA
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with protein-A: 97% inhibition at 0.1 mM, with protein-A: 99% inhibition at 0.1 mM
EGTA
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with protein-A: 100% inhibition at 0.1 mM, without protein-A: 95% inhibition at 0.1 mM
Fe2+
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inhibits the enzyme activity of both preactivated and non-preactivated protein-B
homocysteine
cysteine dioxygenase activity is reduced by 50% only when the molar ratio of homocysteine:cysteine dioxygenase reach about 30000:1
o-phenanthroline
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non-preincubated protein-B: 91% inhibition at 1 mM, with cysteine preincubated protein-B: 67% inhibition at 1 mM
o-phenanthroline
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without protein-A: 96% inhibition at 0.1 mM, with protein A: 100% inhibition at 0.1 mM
additional information
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iodoacetamide has no effect on the enzyme activity; S-methylcysteine does not inhibit cysteine dioxygenase
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additional information
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inhibitors of the 26S proteasome (e.g., proteasome inhibitor 1 and lactacystin) block CDO degradation in cysteine-deficient cells but had little or no effect on CDO concentration in hepatocytes cultured with excess cysteine
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