1.14.99.1: prostaglandin-endoperoxide synthase

This is an abbreviated version!
For detailed information about prostaglandin-endoperoxide synthase, go to the full flat file.

Word Map on EC 1.14.99.1

1.14.99.1

arachidonic

indomethacin

necrosis

nsaid

tnf

lipopolysaccharide

endothelial

nonsteroidal

celecoxib

artery

thromboxane

aspirin

lps

lipoxygenase

pain

cardiovascular

lps-induced

platelet

prostanoids

agonist

gastrointestinal

mapks

phospholipase

gastric

carcinogenesis

eicosanoids

leukotriene

ulcer

arthritis

analgesic

prostacyclin

nf-kappab

lps-stimulated

colorectal

angiogenesis

edema

tnf-alpha

ibuprofen

vasodilator

il-1beta

osteoarthritis

nonselective

factor-alpha

chemopreventive

lipopolysaccharide-induced

factor-kappa

endothelium-dependent

vasoconstriction

l-name

endothelium-derived

medicine

Reaction

+ 2 O2 =

Synonyms

(PG)H synthase, COX, COX-1, COX-2, COX1, Cox2, cyclooxygenase, cyclooxygenase 1, cyclooxygenase 2, cyclooxygenase-1, cyclooxygenase-1b, cyclooxygenase-2, cycloxigenase-2, fatty acid cyclooxygenase, hPGHS-1, hPGHS-2, oPGHS-1, PG G/H synthase 2, PG H synthase, PG synthetase, PG-endoperoxide synthase 2, PG-endoperoxide synthetase, PGH-synthase, PGHS, PGHS isoform-1, PGHS-1, PGHS-2, PHS, PHS-1, PHS-2, prostagladin-H synthase, prostaglandin endoperoxide H synthase, prostaglandin endoperoxide H synthase 1, prostaglandin endoperoxide H synthase 2, prostaglandin endoperoxide H synthase-1, prostaglandin endoperoxide H2 synthase-2, prostaglandin endoperoxide synthase, prostaglandin endoperoxide synthase 2, prostaglandin endoperoxide synthase-1, prostaglandin endoperoxide synthase-2, prostaglandin endoperoxide synthetase, prostaglandin G/H synthase, prostaglandin G/H synthase-2, prostaglandin H synthase, prostaglandin H synthase-1, prostaglandin H synthase-2, prostaglandin H2 synthase, prostaglandin H2 synthase-1, prostaglandin synthase, prostaglandin synthase-2, prostaglandin synthetase, prostaglandin-endoperoxide synthase, prostaglandin-endoperoxide synthase 1, prostaglandin-endoperoxide synthase 2, prostaglandin-H-synthase, prostaglandin-H-synthase 1, prostaglandin-H-synthase 2, PTGS 2, PTGS-1, PTGS-2, PTGS1, PTGS2, putative cyclooxygenase-3, synthase, prostaglandin, tPGHS-1, tPGHS-2

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.99 Miscellaneous

1.14.99.1 prostaglandin-endoperoxide synthase

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Results	in table
40	Activating Compound
2844	AA Sequence
6	Application
2	CAS Registry Number
27	Cloned(Commentary)
17	Cofactor
3	Crystallization (Commentary)
87524	Disease/ Diagnostics
11	Expression
19	General Information
5	General Stability
34	IC50 Value
221	Inhibitors
3	kcat/KM [mM/s]
5	Ki Value [mM]
101	KM Value [mM]
30	Localization
6	Metals/Ions
17	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
123	Organism
8	Pathway
210	PDB ID
24	pH Optimum
2	pH Range
1	pH Stability
5	Posttranslational Modification
66	Protein Variants
20	Purification (Commentary)
3	Reaction
34	Reaction Type
112	Reference
1	Renatured (Commentary)
121	Source Tissue
9	Specific Activity [micromol/min/mg]
3	Storage Stability
117	Substrates and Products (Substrate)
12	Subunits
216	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
3	Temperature Range [°C]
2	Temperature Stability [°C]
3	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.14.99.1 - prostaglandin-endoperoxide synthase

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0.00039 - 0.00298

5-amino-2-hydroxy-N-(propan-2-yl)benzamide

2 entries

0.00019 - 0.0083

5-amino-N-cyclohexyl-2-hydroxybenzamide

2 entries

0.00022 - 0.0097

5-amino-N-hexyl-2-hydroxybenzamide

2 entries

0.00033 - 0.0098

5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-N-(4-methylphenyl)benzamide

2 entries

0.003 - 0.0212

alpha-linolenic acid

2 entries

0.000041 - 0.0009

indomethacin

4 entries

0.0026 - 0.0198

linoleic acid

2 entries

0.0001 - 0.0135

N-butyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide

2 entries

0.00011 - 0.0132

N-cyclohexyl-5-[(E)-[(2,5-dihydroxyphenyl)methylidene]amino]-2-hydroxybenzamide

2 entries

0.00011 - 0.0126

N-cyclohexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide

2 entries

0.0001 - 0.0145

N-hexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide

2 entries

0.0026 - 0.0507

NS-398

2 entries

0.1226 - 0.1245

oleic acid

2 entries

0.0186 - 0.0388

peroxynitrite

4 entries

0.018 - 0.086

quercetin

2 entries