1.8.3.2: thiol oxidase
This is an abbreviated version!
For detailed information about thiol oxidase, go to the full flat file.
Word Map on EC 1.8.3.2
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1.8.3.2
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hepatocytes
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intermembrane
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oxidases
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relay
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qsoxs
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thioredoxin
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redox-active
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hepatectomy
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hepatotrophic
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reoxidized
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hepatectomized
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flavoenzyme
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fad-dependent
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fad-binding
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oxidoreductins
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flavin-linked
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redox-regulated
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isoalloxazine
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3h-tdr
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diagnostics
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medicine
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nutrition
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analysis
- 1.8.3.2
- hepatocytes
-
intermembrane
- oxidases
-
relay
-
qsoxs
- thioredoxin
-
redox-active
-
hepatectomy
-
hepatotrophic
-
reoxidized
-
hepatectomized
-
flavoenzyme
-
fad-dependent
-
fad-binding
-
oxidoreductins
-
flavin-linked
-
redox-regulated
- isoalloxazine
-
3h-tdr
- diagnostics
- medicine
- nutrition
- analysis
Reaction
2 R'C(R)SH
+
Synonyms
Ac92, AcMNPV P33, ALR, ALRp, AtSOX, augmenter of liver regeneration, DTT-oxidase, E10R, egg white oxidase, Ero1, Ero1p, ERV/ALR sulfhydryl oxidase, Erv1, Erv1p, Erv2, ERv2p, FAD-linked sulfhydryl oxidase, FAD-linked sulfhydryl oxidase ALR, FAD-sulfhydryl oxidase, flavin adenine dinucleotide-linked sulfhydryl oxidase, flavin-dependent sulfhydryl oxidase, GmQSOX1, GmQSOX2, hepatic regenerative stimulator substance, hepatopoietin, mitochondrial FAD-linked sulfhydryl oxidase ERV1, More, neuroblastoma-derived sulfhydryl oxidase, oxidase, thiol, P33, pB119L, protein pB119L, QSCN6, QSOX, QSOx1, QSOX1b, QSOX2, QSOX3, Quiescin Q6, quiescin Q6 sulfhydryl oxidase, quiescin Q6 sulfhydryl oxidase 1, quiescin Q6/sulfhydryl oxidase, quiescin sulfhydryl oxidase, quiescin sulfhydryl oxidase 1, quiescin sulhydryl oxidase, quiescin-like flavin-dependent sulfhydryl oxidase, Quiescin-sulfhydryl oxidase, quiescin/sulfhydryl oxidase, quiescin/sulfhydryl oxidase 1b, quiescin/sulphydryl oxidase, rQSOX, sfALR, SOX, Sox1, Sox2, SOXN, sulfhydryl oxidase, sulfhydryl oxidase SOx-3, sulfhydryl oxidase, P33, sulphydryl oxidase, thiol oxidase Erv1, thiooxidase
ECTree
1.8.3.2 thiol oxidaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 1.8.3.2 - thiol oxidase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
DTT
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rapid reaction studies show that dithiothreitol generates a transient mixed disulfide intermediate with sfALR signaled by a weak charge-transfer interaction between the thiolate of C145 and the oxidized flavin, reducing the transfer of reducing equivalents and reoxidation of the reduced flavin by molecular oxygen
RNAi
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silences QSOX. Survival of QSOX-silenced insects is reduced over controls following blood digestion, most likely due to the compromised ability of mosquitoes to scavenge and/or prevent damage caused by blood meal-derived oxidative stress. Higher lipid peroxidation and mortality in QSOX-silenced mosquitoes may be an indication that the redox balance is altered in these insects after a blood meal
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EDTA
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inhibition of enzyme from kidney and small intestine, no inhibition of enzyme from skin and seminal vesivles
Zn2+
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weak binding to the four-electron-reduced enzyme, rapid inhibition, modeling of metal binding
Zn2+
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upon coordination with Zn2+, full reduction of Erv2p requires 6 electrons. Strongly inhibits Erv2p when assayed using tris(2-carboxyethyl)phosphine as the reducing substrate of the oxidase. Restoration of 1 mM EDTA effects rapid recovery of 80% of the original activity
