2.1.1.137: arsenite methyltransferase

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For detailed information about arsenite methyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

Synonyms

AdoMet:arsenic(III) methyltransferase, arsenic (+3 oxidation state) methyltransferase, arsenic (+3 oxidation state)-methyltransferase, arsenic (+3) methyltransferase, arsenic (III) methyltransferase, arsenic (III) S-adenosylmethionine methyltransferase, arsenic methyltransferase Cyt19, arsenic(III) methyltransferase, arsenite (+3 oxidation state) methyltransferase, arsenite methyltransferase, arsenite S-adenosylmethionine methyltransferase, ArsM, ArsM protein, ArsM7B, As(III) methyltransferase, As(III) S-adenosylmethionine methyltransferase, As(III) SAM methyltransferase, AS3MT, AsIII S-adenosylmethionine methyltransferase, Cyr19, Cyt19, EC 2.1.1.138, hAS3MT, methylarsonite methyltransferase, N6AMT1, S-adenosyl-L-methionine:arsenic(III) methyltransferase, S-adenosyl-L-methionine:methylarsonite As-methyltransferase, S-adenosylmethionine dependent arsenic methyltransferase, [As(III)] methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.137 arsenite methyltransferase

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Results	in table
24	Activating Compound
213	AA Sequence
2	Application
1	CAS Registry Number
38	Cloned(Commentary)
19	Cofactor
4	Crystallization (Commentary)
114	Disease/ Diagnostics
3	Expression
10	General Information
17	Inhibitors
2	Ki Value [mM]
41	KM Value [mM]
8	Localization
12	Molecular Weight [Da]
52	Natural Substrates/ Products (Substrates)
96	Organism
2	PDB ID
11	pH Optimum
2	pH Range
55	Protein Variants
17	Purification (Commentary)
15	Reaction
1	Reaction Type
81	Reference
62	Source Tissue
11	Specific Activity [micromol/min/mg]
93	Substrates and Products (Substrate)
14	Subunits
114	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]

Application

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Application on EC 2.1.1.137 - arsenite methyltransferase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

degradation

Cyanidioschyzon sp. 5508

C0JV69

Bacillus subtilis 168 expressing ArsM converts most of the inorganic As in the medium into dimethylarsenate and trimethylarsine oxide within 48 h and volatizes substantial amounts of dimethylarsine and trimethylarsine. The rate of As methylation and volatilization increases with temperature from 37 to 50°C. When inoculated into an As-contaminated organic manure composted at 50°C, the modified strain significantly enhances As volatilization

755840

medicine

Homo sapiens

Q9HBK9

the proliferation of NB4 cells is significantly inhibited in a transwell system cocultured with AS3MT-transfected HepG2 cells after exposure to arsenite. The therapeutic efficacy of As2O3 (i.e., iAsIII) in acute promyelocytic leukemia patients is probably associated with the production of methylated arsenic metabolites by AS3MT

757579