2.1.1.137: arsenite methyltransferase

This is an abbreviated version!
For detailed information about arsenite methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.137

2.1.1.137

dimethylarsinic

monomethylarsonic

trivalent

arsenic-induced

arsenic-related

metalloid

trimethylarsine

biomethylation

dmasiii

dimethylarsenate

gstos

organoarsenical

hplc-icpms

arsenic-contaminated

methylarsenicals

cyanidioschyzon

as-contaminated

arsenic-exposed

methylarsonic

medicine

degradation

Reaction

2 S-adenosyl-L-methionine +

+ 2 thioredoxin +

+ 3 glutathione + 2 thioredoxin disulfide

Synonyms

AdoMet:arsenic(III) methyltransferase, arsenic (+3 oxidation state) methyltransferase, arsenic (+3 oxidation state)-methyltransferase, arsenic (+3) methyltransferase, arsenic (III) methyltransferase, arsenic (III) S-adenosylmethionine methyltransferase, arsenic methyltransferase Cyt19, arsenic(III) methyltransferase, arsenite (+3 oxidation state) methyltransferase, arsenite methyltransferase, arsenite S-adenosylmethionine methyltransferase, ArsM, ArsM protein, ArsM7B, As(III) methyltransferase, As(III) S-adenosylmethionine methyltransferase, As(III) SAM methyltransferase, AS3MT, AsIII S-adenosylmethionine methyltransferase, Cyr19, Cyt19, EC 2.1.1.138, hAS3MT, methylarsonite methyltransferase, N6AMT1, S-adenosyl-L-methionine:arsenic(III) methyltransferase, S-adenosyl-L-methionine:methylarsonite As-methyltransferase, S-adenosylmethionine dependent arsenic methyltransferase, [As(III)] methyltransferase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.137 arsenite methyltransferase

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Results	in table
24	Activating Compound
213	AA Sequence
2	Application
1	CAS Registry Number
38	Cloned(Commentary)
19	Cofactor
4	Crystallization (Commentary)
114	Disease/ Diagnostics
3	Expression
10	General Information
17	Inhibitors
2	Ki Value [mM]
41	KM Value [mM]
8	Localization
12	Molecular Weight [Da]
52	Natural Substrates/ Products (Substrates)
96	Organism
2	PDB ID
11	pH Optimum
2	pH Range
55	Protein Variants
17	Purification (Commentary)
15	Reaction
1	Reaction Type
81	Reference
62	Source Tissue
11	Specific Activity [micromol/min/mg]
93	Substrates and Products (Substrate)
14	Subunits
114	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 2.1.1.137 - arsenite methyltransferase

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arsenite

Danio rerio

the enzyme activity is completely inhibited by elevated concentrations of the substrate arsenite (0.2 mM)

721074

dimethylselenoxide

2 entries

glutathione

Homo sapiens

addition of 20 mM GSH sharply inhibits methylation

721075

GSH

3 entries

HgCl2

Oryctolagus cuniculus

485152

methylselenic acid

2 entries

selenate

Oryctolagus cuniculus

more than 1 mM selenate necessary for 50% inhibition

485152

Selenite

2 entries

Sodium selenite

2 entries

trimethyl-selenonium iodide

Homo sapiens

weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes

658442

trimethylselenonium iodide

Rattus norvegicus

weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes

658442