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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsenate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsenate(III)
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate + dimethylarsinate + trimethylarsine
Cyanidioschyzon sp.
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the first product, methylarsonate, undergoes a second round of methylation faster than it dissociates from the enzyme. The second product, dimethylarsinate, dissociates faster than it undergoes the third round of methylation to the third and final product, trimethylarsine
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate + dimethylarsinous acid + dimethylarsinic acid
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + monomethylarsonate + dimethylarsinic acid
S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + monomethylarsonous acid + monomethylarsonic acid + dimethylarsinic acid
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the enzyme methylates arsenite to dimethylarsinic acid as an end product and produces monomethylarsonous acid and monomethylarsonic acid as intermediates
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S-adenosyl-L-methionine + methylarsinate
S-adenosyl-L-homocysteine + dimethylarsinate
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S-adenosyl-L-methionine + methylarsonate
S-adenosyl-L-homocysteine + dimethylarsinous acid
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S-adenosyl-L-methionine + methylarsonate
S-adenosyl-L-homocysteine + dimethylarsinous acid + dimethylarsinic acid
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
S-adenosyl-L-methionine + phenylarsenite
S-adenosyl-L-homocysteine + phenylmethylarsenate(III)
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additional information
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
Cyanidioschyzon sp.
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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AS3MT may contribute to variation in arsenic metabolism and, perhaps, arsenic-dependent carcinogenesis in humans
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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hAS3MT is the key enzyme in the pathway for methylation of iAs in human hepatic cells
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
As3MT enzyme is indispensable for conversion of the arsenic metabolites to their corresponding methylated products, metabolism of arsenic proceeds through sequential reduction and oxidative methylation involving several enzymes including the arsenic (+3) methyltransferase, overview
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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methylation of environmental arsenic by conversion to soluble and gaseous methylated species is a detoxifying process that may contribute to global cycling of arsenic
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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ArsM catalyzes the formation of a number of methylated intermediates from arsenite, with trimethylarsine as the end product
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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methylation of environmental arsenic by conversion to soluble and gaseous methylated species is a detoxifying process that may contribute to global cycling of arsenic
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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ArsM catalyzes the formation of a number of methylated intermediates from arsenite, with trimethylarsine as the end product
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + methylarsonate
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + monomethylarsonate + dimethylarsinic acid
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S-adenosyl-L-methionine + arsenite
S-adenosyl-L-homocysteine + monomethylarsonate + dimethylarsinic acid
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maximal conversion of arsenite to monomethylarsonate occurs at about 0.1 mM arsenite. Higher substrate concentrations inhibit monomethylarsonate yields. The production of dimethylarsinic acid increases as arsenite concentration increases from 0.0005 to 0.0083 mM, and then quickly decreases to zero
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
Cyanidioschyzon sp.
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
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the enzyme also produces also produces dimethylarsine and trimethylarsine gases as by-products
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
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the enzyme also produces also produces dimethylarsine and trimethylarsine gases as by-products
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
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S-adenosyl-L-methionine + methylarsonite
S-adenosyl-L-homocysteine + dimethylarsinate
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additional information
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upon incubation with arsenite, dimethylarsinate and a small amount of methylarsinate are detected in the reaction system within 0.5 h
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additional information
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enzyme evolutionary analysis
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additional information
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enzyme evolutionary analysis
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additional information
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enzyme evolutionary analysis
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additional information
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enzyme evolutionary analysis
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additional information
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monomethylarsonous acid is not methylated
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additional information
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As3MT methylates inorganic arsenic and its metabolites
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additional information
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enzyme evolutionary analysis
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additional information
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genetic susceptibility to arsenic toxicity in Asian is different from Africans and Caucasians, overview
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additional information
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genetic susceptibility to arsenic toxicity in Asian is different from Africans and Caucasians, overview
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additional information
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the enzyme does not methylate selenium and tellurium
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additional information
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enzyme evolutionary analysis
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additional information
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enzyme evolutionary analysis
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additional information
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enzyme evolutionary analysis
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additional information
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enzyme evolutionary analysis
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additional information
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enzyme evolutionary analysis
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additional information
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enzyme evolutionary analysis
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additional information
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the enzyme is responsible for the removal of arsenic as the volatile arsines from the bacteria producing trimethylarsine via successive methylation
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additional information
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enzyme evolutionary analysis
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additional information
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besides methylarsonate and dimethylarsinate, the enzyme also produces trimethylarsenite and dimethylarsine gases
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