2.1.1.244: protein N-terminal methyltransferase
This is an abbreviated version!
For detailed information about protein N-terminal methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.244
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2.1.1.244
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methyltransferases
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rna-dependent
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mtase
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trimethylation
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dengue
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flavivirus
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bisubstrate
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methyltransferase-like
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drug development
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pharmacology
- 2.1.1.244
- methyltransferases
-
rna-dependent
- mtase
-
trimethylation
- dengue
- flavivirus
-
bisubstrate
-
methyltransferase-like
- drug development
- pharmacology
Reaction
2 S-adenosyl-L-methionine
+
Synonyms
alpha-N-methyltransferase, alpha-N-terminal methyltransferase 1, alphaN-methyltransferase, CG1675, dNTMT, EEF1A lysine methyltransferase 1, eEF1A-KMT1, EEF1AKMT1, Efm5, Efm7, elongation factor methyltransferase 7, FEAT, METT11B, METTL11A, METTL11a/C9orf32/Ad-003, METTL13, METTL13/FEAT, N-terminal and lysine methyltransferase, N-terminal methyltransferase, N-terminal methyltransferase 1, N-terminal RCC1 methyltransferase, N-terminal RCC1 methyltransferase 1, N-terminal Xaa-Pro-Lys N-methyltransferase 1, N6AMT2, NMT1, NNT1, NRMT, NRMT1, Ntm1, NTMT1, peptide N-terminal methyltransferase, PrmA, protein methyltransferase, protein N-terminal methyltransferase 1, Rkm2, SS alphaN-methyltransferase, SSMT, TAE1, YBR261C, YBR261C/Tae1, YGR001C, YLR285W
ECTree
2.1.1.244 protein N-terminal methyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.1.1.244 - protein N-terminal methyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3 S-adenosyl-L-methionine + eukaryotic elongation factor 1A
3 S-adenosyl-L-homocysteine + ?
3 S-adenosyl-L-methionine + GPKRIA
3 S-adenosyl-L-homocysteine + ?
trimethylation by NTMT1
-
-
?
3 S-adenosyl-L-methionine + N-terminal-OLA1
3 S-adenosyl-L-homocysteine + ?
i.e. Obg-like ATPase 1 (OLA1) protein, target validation using normal and NTMT1 knockout HEK-293FT cells demonstrates that OLA1, a protein involved in many critical cellular functions, is methylated in vivo by NTMT1
-
-
?
3 S-adenosyl-L-methionine + N-terminal-PPKRIA-[RCC1]
3 S-adenosyl-L-homocysteine + N-terminal-trimethyl-PPKRIA-[RCC1]
-
-
-
?
L-lysyl-[protein] + 3 S-adenosyl-L-methionine
3 H+ + N6,N6,N6-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine
N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein]
S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein]
-
-
-
?
S-adenosyl-L-methionine + N-terminal-CENP-A
S-adenosyl-L-homocysteine + ?
human CENP-A histone
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-
?
S-adenosyl-L-methionine + N-terminal-histone 2B
S-adenosyl-L-homocysteine + ?
fruit fly histone 2B
-
-
?
S-adenosyl-L-methionine + Ran guanine nucleotide-exchange factor RCC1
S-adenosyl-L-homocysteine + ?
-
NRMT is the predominant alpha-N-methyltransferase for RCC1
-
-
?
S-adenosyl-L-methionine + retinoblastoma protein
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + Rpl12ab
?
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methylation of Rpl12ab at the N-terminal proline residue
-
-
?
3 S-adenosyl-L-methionine + eukaryotic elongation factor 1A
3 S-adenosyl-L-homocysteine + ?
enzyme N6AMT2 trimethylates eEF1A at the N-terminal site and at the adjacent lysine 79, protein substrate from Homo sapiens or Saccharomyces cerevisiae
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-
?
3 S-adenosyl-L-methionine + eukaryotic elongation factor 1A
3 S-adenosyl-L-homocysteine + ?
enzyme N6AMT2 trimethylates eEF1A at the N-terminal site and at the adjacent lysine 79, protein substrate from Homo sapiens or Saccharomyces cerevisiae
-
-
?
3 S-adenosyl-L-methionine + eukaryotic elongation factor 1A
3 S-adenosyl-L-homocysteine + ?
enzyme N6AMT2 trimethylates eEF1A at the N-terminal site and at the adjacent lysine 79, protein substrate from Homo sapiens or Saccharomyces cerevisiae
-
-
?
3 S-adenosyl-L-methionine + N-terminal-[eEF1A]
3 S-adenosyl-L-homocysteine + ?
-
-
-
?
3 S-adenosyl-L-methionine + N-terminal-[eEF1A]
3 S-adenosyl-L-homocysteine + ?
-
-
-
?
3 S-adenosyl-L-methionine + N-terminal-[eEF1A]
3 S-adenosyl-L-homocysteine + ?
-
-
-
?
3 S-adenosyl-L-methionine + N-terminal-[RCC1]
3 S-adenosyl-L-homocysteine + ?
-
-
-
?
3 S-adenosyl-L-methionine + N-terminal-[RCC1]
3 S-adenosyl-L-homocysteine + ?
-
-
-
?
L-lysyl-[protein] + 3 S-adenosyl-L-methionine
3 H+ + N6,N6,N6-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
-
-
-
?
L-lysyl-[protein] + 3 S-adenosyl-L-methionine
3 H+ + N6,N6,N6-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
-
-
-
?
L-lysyl-[protein] + 3 S-adenosyl-L-methionine
3 H+ + N6,N6,N6-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
-
-
-
?
L-lysyl-[protein] + 3 S-adenosyl-L-methionine
3 H+ + N6,N6,N6-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
-
-
-
?
N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine
N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
-
-
-
?
N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine
N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
-
-
-
?
N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine
N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
-
-
-
?
N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine
N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine
-
-
-
?
S-adenosyl-L-methionine + Rpl12ab
S-adenosyl-L-homocysteine + ?
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the yeast Rpl12ab protein is dimethylated at the N-terminal proline residue, trimethylated at Lys-3 by Rkm2, and monomethylated at Arg66
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-
?
S-adenosyl-L-methionine + Rpl12ab
S-adenosyl-L-homocysteine + ?
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the yeast Rpl12ab protein is dimethylated at the N-terminal proline residue, trimethylated at Lys-3 by Rkm2, and monomethylated at Arg66
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-
?
additional information
?
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alpha-N-terminal methylation of histone H2B protein in Drosophila melanogaster
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-
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additional information
?
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PrmA preferentially methylates free ribosomal protein L11 over an assembled 50S ribosomal subunit
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-
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additional information
?
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the protein N-terminal methyltransferase 1 (NTMT1) methylates the alpha-N-terminal amines of proteins
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-
?
additional information
?
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human MTase-like protein 13 (METTL13) is a dual MTase for both N-terminal Gly1 and Lys55 of human eEF1A. To date, eEF1A is the only validated biological substrate for METTL13
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-
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additional information
?
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human MTase-like protein 13 (METTL13) is a dual MTase for both N-terminal Gly1 and Lys55 of human eEF1A. To date, eEF1A is the only validated biological substrate for METTL13
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additional information
?
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protein N-terminal methyltransferase 1 (NTMT1/NRMT1) catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to protein alpha-N-terminal amines. It recognizes a specific motif X-P-K/R (X represents any amino acid other than D/E)
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additional information
?
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substrate of NTMT1 are regulator of chromosome condensation 1 (RCC1), tumor suppressor retinoblastoma1 (RB1), oncoprotein SET (also known as I2PP2A, TAF1a), damaged DNA-binding protein2 (DDB2), poly(ADP-ribose) polymerase3 (PARP3), and centromere proteins A and B
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-
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additional information
?
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substrate of NTMT1 are regulator of chromosome condensation 1 (RCC1), tumor suppressor retinoblastoma1 (RB1), oncoprotein SET (also known as I2PP2A, TAF1a), damaged DNA-binding protein2 (DDB2), poly(ADP-ribose) polymerase3 (PARP3), and centromere proteins A and B
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-
-
additional information
?
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the methyltransferase N6AMT2 is responsible for Lys79 methylation of human eEF1A, but has been previously documented as a putative N(6)-adenine-specific DNA methyltransferase. It is renamed eEF1A-KMT1
-
-
-
additional information
?
-
-
the methyltransferase N6AMT2 is responsible for Lys79 methylation of human eEF1A, but has been previously documented as a putative N(6)-adenine-specific DNA methyltransferase. It is renamed eEF1A-KMT1
-
-
-
additional information
?
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the N-terminal protein methyltransferase catalyzes the modification of two ribosomal protein substrates, Rpl12ab and Rps25a/Rps25b. The yeast RPS25A and RPS25B genes and differ only at a single amino acid residue
-
-
?
additional information
?
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the methyltransferase N6AMT2 is responsible for Lys79 methylation of human eEF1A, but has been previously documented as a putative N(6)-adenine-specific DNA methyltransferase. It is renamed eEF1A-KMT1
-
-
-
additional information
?
-
the methyltransferase N6AMT2 is responsible for Lys79 methylation of human eEF1A, but has been previously documented as a putative N(6)-adenine-specific DNA methyltransferase. It is renamed eEF1A-KMT1
-
-
-
additional information
?
-
-
the methyltransferase N6AMT2 is responsible for Lys79 methylation of human eEF1A, but has been previously documented as a putative N(6)-adenine-specific DNA methyltransferase. It is renamed eEF1A-KMT1
-
-
-
additional information
?
-
YLR285W, also named elongation factor methyltransferase 7 (Efm7), is a dual MTase that installs methyl groups at both N-terminal Gly1 and Lys2 residues of yeast eEF1A protein. Lys2 is methylated only after trimethylation of Gly1. Yeast eEF1A starts with GKEKSHINV and is the only known substrate of Efm7, although there are 35 other yeast proteins with a G-K sequence at their N termini. But Efm7 is not able to methylate the synthetic decamer peptide GKEKSHINVV derived from the N-terminus of eEF1A
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-
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additional information
?
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YLR285W, also named elongation factor methyltransferase 7 (Efm7), is a dual MTase that installs methyl groups at both N-terminal Gly1 and Lys2 residues of yeast eEF1A protein. Lys2 is methylated only after trimethylation of Gly1. Yeast eEF1A starts with GKEKSHINV and is the only known substrate of Efm7, although there are 35 other yeast proteins with a G-K sequence at their N termini. But Efm7 is not able to methylate the synthetic decamer peptide GKEKSHINVV derived from the N-terminus of eEF1A
-
-
-
additional information
?
-
the methyltransferase N6AMT2 is responsible for Lys79 methylation of human eEF1A, but has been previously documented as a putative N(6)-adenine-specific DNA methyltransferase. It is renamed eEF1A-KMT1
-
-
-
additional information
?
-
the methyltransferase N6AMT2 is responsible for Lys79 methylation of human eEF1A, but has been previously documented as a putative N(6)-adenine-specific DNA methyltransferase. It is renamed eEF1A-KMT1
-
-
-
additional information
?
-
YLR285W, also named elongation factor methyltransferase 7 (Efm7), is a dual MTase that installs methyl groups at both N-terminal Gly1 and Lys2 residues of yeast eEF1A protein. Lys2 is methylated only after trimethylation of Gly1. Yeast eEF1A starts with GKEKSHINV and is the only known substrate of Efm7, although there are 35 other yeast proteins with a G-K sequence at their N termini. But Efm7 is not able to methylate the synthetic decamer peptide GKEKSHINVV derived from the N-terminus of eEF1A
-
-
-
additional information
?
-
YLR285W, also named elongation factor methyltransferase 7 (Efm7), is a dual MTase that installs methyl groups at both N-terminal Gly1 and Lys2 residues of yeast eEF1A protein. Lys2 is methylated only after trimethylation of Gly1. Yeast eEF1A starts with GKEKSHINV and is the only known substrate of Efm7, although there are 35 other yeast proteins with a G-K sequence at their N termini. But Efm7 is not able to methylate the synthetic decamer peptide GKEKSHINVV derived from the N-terminus of eEF1A
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-
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additional information
?
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the substrate recognition motif is M-L/M/K-G/Q. PrmA preferentially methylates free ribosomal protein L11 over an assembled 50S ribosomal subunit
-
-
-
additional information
?
-
the substrate recognition motif is M-L/M/K-G/Q. PrmA preferentially methylates free ribosomal protein L11 over an assembled 50S ribosomal subunit
-
-
-
additional information
?
-
the substrate recognition motif is M-L/M/K-G/Q. PrmA preferentially methylates free ribosomal protein L11 over an assembled 50S ribosomal subunit
-
-
-
