2.1.1.296: methyltransferase cap2

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For detailed information about methyltransferase cap2, go to the full flat file.

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Synonyms

AFT, cap2, cap2-MTase, CMTr2, FLJ11171, FTSJD1, hMTr2, mRNA (nucleoside-2'-O)-methyltransferase, MT48, MT57, MTR2, TbMT48, TbMT57

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.296 methyltransferase cap2

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Systematic Name on EC 2.1.1.296 - methyltransferase cap2

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-ribonucleotide-[mRNA] 2'-O-methyltransferase

The enzyme, found in higher eukaryotes including insects and vertebrates, and their viruses, methylates the ribose of the ribonucleotide at the second transcribed position of mRNAs and snRNAs. This methylation event is known as cap2. The human enzyme can also methylate mRNA molecules where the upstream ribonucleotide is not methylated (see EC 2.1.1.57, methyltransferase cap1), but with lower efficiency [2].