2.1.1.37: DNA (cytosine-5-)-methyltransferase

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For detailed information about DNA (cytosine-5-)-methyltransferase, go to the full flat file.

Reaction

Synonyms

5-cytosine DNA methyltransferase, C5 MTase, C5-MTase, CG recognizing DNA methyltransferase SssI, CMT1, CMT3, cytosine 5-methyltransferase, cytosine carbon 5 DNA methyltransferase, cytosine DNA methylase, cytosine DNA methyltransferase, cytosine DNA MTase, cytosine-5 methyltransferase, cytosine-specific DNA methyltransferase, DCM, DCMT, deoxyribonucleate methylase, deoxyribonucleate methyltransferase, deoxyribonucleic (cytosine-5-)-methyltransferase, deoxyribonucleic acid (cytosine-5-)-methyltransferase, deoxyribonucleic acid methylase, deoxyribonucleic acid methyltransferase, deoxyribonucleic acid modification methylase, deoxyribonucleic methylase, DMT1, DNA (cytosine-5) methyltransferase, DNA (cytosine-5)-methyltransferase 1, DNA (cytosine-5)-methyltransferase 2, DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3B, DNA (cytosine-5-)-methyltransferase 3A, DNA (cytosine-C5) methyltransferase, DNA 5-cytosine methylase, DNA cytosine C(5)-methyltransferase, DNA cytosine c5 methylase, DNA cytosine methylase, DNA cytosine methyltransferase, DNA cytosine-5 methyltransferase 1, DNA cytosine-5-methyltransferase 1, DNA cytosine-5-methyltransferase 3A, DNA cytosine-5-methyltransferase 3B, DNA methylase, DNA methyltransferase, DNA methyltransferase 1, DNA methyltransferase 3a, DNA methyltransferase-1, DNA MTase, DNA transmethylase, DNA-cytosine 5-methylase, DNA-cytosine methyltransferase, DNA-methyltransferase, DNMT, Dnmt1, Dnmt1 DNA-(cytosine-C5)-methyltransferase, DNMT1 methyltransferase, Dnmt1o, Dnmt2, Dnmt3, Dnmt3a, DNMT3B, DNMT3b2, DNMTB, DRM1/2, EC 2.1.1.73, EcoRI methylase, EcoRII DNA-cytosine methylase, EhMeth, hDNMT1, hhaIM, HpaII, M.BssHII, M.BsuRIa, M.BsuRIb, M.EcoHK31l, M.HhaI, M.HhaIII, M.MpeI, M.MspI, M.SsoII, M.Ssp6803I, M.SssI, MarII, MET1, MET1B, methylphosphotriester-DNA methyltransferase, methyltransferase, deoxyribonucleate, More, MspI DNA methyltransferase, MYPE4940, NSUN2, Nt-DRM1, SinI DNA methyltransferase, SsoII, ssoIIM, SSSI, sssIM, ssssIM, type II DNA methylase, Z2389, Zmt3

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.37 DNA (cytosine-5-)-methyltransferase

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Results	in table
10	Activating Compound
54547	AA Sequence
3	Application
1	CAS Registry Number
46	Cloned(Commentary)
34	Cofactor
5	Crystallization (Commentary)
13317	Disease/ Diagnostics
3	Expression
23	General Information
1	General Stability
44	IC50 Value
135	Inhibitors
35	Ki Value [mM]
81	KM Value [mM]
31	Localization
1	Metals/Ions
23	Molecular Weight [Da]
68	Natural Substrates/ Products (Substrates)
167	Organism
4	Pathway
187	PDB ID
13	pH Optimum
2	pH Range
2	Posttranslational Modification
57	Protein Variants
33	Purification (Commentary)
8	Reaction
1	Reaction Type
144	Reference
87	Source Tissue
12	Specific Activity [micromol/min/mg]
13	Storage Stability
246	Substrates and Products (Substrate)
17	Subunits
227	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
7	Temperature Stability [°C]
34	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 2.1.1.37 - DNA (cytosine-5-)-methyltransferase

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

phosphoprotein

Homo sapiens

-

IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase

685922

proteolytic modification

Paracentrotus lividus

-

at blastula stage a proteolytic mechanism hydrolyses the enzyme present in all embryonic cells by removing a peptide of about 45000 Da from the amino terminal region of the 190000 Da enzyme initially synthesized on maternal transcripts. The resulting 145000 Da enzyme shows modified catalytic properties, different antibody reactivity and is rapidly destroyed in the few hours before gastrulation

485293