2.3.1.13: glycine N-acyltransferase

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For detailed information about glycine N-acyltransferase, go to the full flat file.

Reaction

Synonyms

acyltransferase, glycine, GlyAT, GLYATL1, GLYATL2, GLYATL3, glycine acyltransferase, glycine N-acyltransferase, glycine N-acyltransferase-like 3, glycine-N-acylase, glycine-N-acyltransferase, glycine-N-acyltransferase like 1

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.13 glycine N-acyltransferase

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Results	in table
15	AA Sequence
2	Application
6	Cloned(Commentary)
45	Disease/ Diagnostics
2	Expression
4	General Information
2	General Stability
2	IC50 Value
29	Inhibitors
11	kcat/KM [mM/s]
6	Ki Value [mM]
63	KM Value [mM]
11	Localization
6	Metals/Ions
12	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
28	Organism
5	PDB ID
6	pH Optimum
1	pH Range
1	pI Value
22	Protein Variants
11	Purification (Commentary)
3	Reaction
27	Reference
39	Source Tissue
11	Specific Activity [micromol/min/mg]
2	Storage Stability
70	Substrates and Products (Substrate)
13	Subunits
19	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
11	Turnover Number [1/s]

General Information

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General Information on EC 2.3.1.13 - glycine N-acyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Homo sapiens

Q6IB77

5 novel single nucleotide polymorphisms of the GlyAT gene, including a polymorphism resulting in an amino acid change of Arg131His, in Japanese individuals are identified. The allelic frequency of this polymorphism in Japanese is 0.005, and none possessed this single nucleotide polymorphism among 31 caucasian individuals. Three genetic polymorphisms, 7527 T to A, 21289G to A and 21364A to G, cause the amino acid changes

703426

metabolism

Homo sapiens

Q6IB77

the enzyme activity affects mitochondrial ATP production, glycine availability, free coenzyme A availability, and the toxicity of various organic acids

736070

physiological function

2 entries

physiological function

Homo sapiens

Q6IB77

the enzyme plays a role in liver cancer and musculoskeletal development

736070

physiological function

Mus musculus

E9Q5L8

siRNA knockdown of GLYATL3 in N18TG2 cells results in a decrease in the levels of N-acylglycines and primary fatty acid amides

757373