2.3.1.184: acyl-homoserine-lactone synthase

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For detailed information about acyl-homoserine-lactone synthase, go to the full flat file.

Reaction

Synonyms

3-oxo-C12-HSL synthase, AbaI, ACII, acyl homoserine lactone synthase, acyl-homoserine lactone synthase, acyl-homoserine-lactone synthase, acyl-homoserinelactone synthase, acyl-HSL synthase, acylhomoserine lactone synthase, AHL synthase, AHS, AHSL synthase, AhyI, AinS, AinS protein, AurI, autoinducer synthase, autoinducer synthesis protein rhlI, C4-HSL synthase, C6-AHL synthase, CsaI, EsaI, ExpI, expIEcz, ExpISCC1, ExpISCC3065, hdtS, HHL synthase, LasI, LasI synthase, LasI/R, LasR, LuxI, LuxI protein, LuxM, More, MrlI1, MrlI2, MrtI, mtqI, N-acyl homoserine lactone synthase, N-acyl-homoserine lactone synthase, N-hexanoyl homoserine lactone synthase, NmuI, Nmul_A2390, PgaI, PhzI, PppuI, PsyI, RhlI, RhlI/R, signal synthase CviI, SmaI, SpnI, TofI, TraI, YenI, YpeRI, YspI, YspRI

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.184 acyl-homoserine-lactone synthase

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Results	in table
4	Activating Compound
6328	AA Sequence
5	Application
1	CAS Registry Number
27	Cloned(Commentary)
4	Crystallization (Commentary)
10	Expression
66	General Information
26	Inhibitors
19	KM Value [mM]
1	Metals/Ions
3	Molecular Weight [Da]
85	Natural Substrates/ Products (Substrates)
84	Organism
3	Pathway
1	PDB ID
4	pH Optimum
3	pH Range
1	pI Value
49	Protein Variants
7	Purification (Commentary)
9	Reaction
72	Reference
3	Specific Activity [micromol/min/mg]
137	Substrates and Products (Substrate)
5	Subunits
158	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Range [°C]
4	Turnover Number [1/s]

Application

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Application on EC 2.3.1.184 - acyl-homoserine-lactone synthase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

degradation

2 entries

drug development

2 entries

medicine

Acinetobacter baumannii

B0FLN1

Acinetobacter baumannii is an important nosocomial pathogen and can cause a variety of infections including wound infection, bloodstrem infection, ventilator-acquired pneumonia, and urinary tract infections

687413

degradation

Pseudomonas aeruginosa

-

a significant positive correlation is observed between isoform LasI expression and polycyclic aromatic hydrocarbon degradation. Expression of isoform LasI increases with increase in biofilm growth, while the expression of isoform RhlI decreases during log phase of biofilm growth. Degradation of phenanthrene and pyrene by Pseudomonas aeruginosa N6P6 is affected by biofilm growth and LasI expression. The respective phenanthrene degradation for 15, 24, 48, and 72 h old biofilm after 7 days is 21.5, 54.2, 85.6, and 85.7%. The corresponding pyrene degradation is 15, 18.28, 47.56, and 46.48%, respectively, after 7 days

735547

degradation

Pseudomonas aeruginosa N6P6

-

a significant positive correlation is observed between isoform LasI expression and polycyclic aromatic hydrocarbon degradation. Expression of isoform LasI increases with increase in biofilm growth, while the expression of isoform RhlI decreases during log phase of biofilm growth. Degradation of phenanthrene and pyrene by Pseudomonas aeruginosa N6P6 is affected by biofilm growth and LasI expression. The respective phenanthrene degradation for 15, 24, 48, and 72 h old biofilm after 7 days is 21.5, 54.2, 85.6, and 85.7%. The corresponding pyrene degradation is 15, 18.28, 47.56, and 46.48%, respectively, after 7 days

-

drug development

Burkholderia glumae

-

synthetic inhibitors of acyl-HSL synthases might be useful therapeutically for controlling pathogens

720916

drug development

Burkholderia glumae BGR1

-

synthetic inhibitors of acyl-HSL synthases might be useful therapeutically for controlling pathogens

-