2.3.1.199: very-long-chain 3-oxoacyl-CoA synthase

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For detailed information about very-long-chain 3-oxoacyl-CoA synthase, go to the full flat file.

Reaction

Synonyms

3-ketoacyl CoA synthase, 3-ketoacyl-CoA synthase, acyl-CoA elongase, At1g01120, At2g26640, beta-ketoacyl CoA synthase, beta-ketoacyl-CoA synthase, Cer-zh, CER2-LIKE1, CER2-LIKE2, CER26, CER26L, CER6, CER60, condensing enzyme, Cut1, CUT1L, EC 2.3.1.119, ECERIFERUM 26, ECERIFERUM 26-like, ELO, ELo1, Elo1p, Elo2p, Elo3p, EloA, ELOVL1, ELOVL5, Elovl6, ELOVL7, FA elongase, FAE1, FAE1 beta-ketoacyl-CoA synthase, FAE1 KCS, Fatty acid elongase, fatty acid elongase 1, fatty acid elongation 1, fatty acid elongation1, KCS, Kcs1, KCS17, KCS2, KCS2/DAISY, KCS20, MALCE1, microsomal fatty acid elongase, Onion2, Os03g0220100, Os10 g0416200, seed-specific condensing enzyme, very-long-chain fatty acid condensing enzyme, very-long-chain fatty acid-condensing enzyme, VLCFA condensing enzyme, VLCFA elongase, WSL4

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.199 very-long-chain 3-oxoacyl-CoA synthase

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Results	in table
2	Activating Compound
19614	AA Sequence
1	Application
1	CAS Registry Number
11	Cloned(Commentary)
1	Cofactor
138	Disease/ Diagnostics
11	Expression
27	General Information
6	IC50 Value
7	Inhibitors
6	KM Value [mM]
11	Localization
1	Metals/Ions
7	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
37	Organism
16	Pathway
2	PDB ID
2	pH Optimum
1	pI Value
1	Posttranslational Modification
17	Protein Variants
3	Purification (Commentary)
1	Reaction
32	Reference
1	Renatured (Commentary)
48	Source Tissue
52	Substrates and Products (Substrate)
6	Subunits
95	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

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Application on EC 2.3.1.199 - very-long-chain 3-oxoacyl-CoA synthase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

Homo sapiens

A1L3X0

human cytomegalovirus HMCV induces isoform ELOVL7 by more than 150fold. The induction is dependent on mTOR and SREBP-1. ELOVL7 knockdown or mTOR inhibition impairs HCMV-induced fatty acid elongation, HCMV particle release, and infectivity per particle. ELOVL7 overexpression enhances HCMV replication. During HCMV infection, mTOR activity is maintained by the viral protein pUL38. Expression of pUL38 is sufficient to induce ELOVL7, and pUL38-deficient virus is partially defective in ELOVL7 induction and fatty acid elongation

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