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2.3.1.206: 3,5,7-trioxododecanoyl-CoA synthase

This is an abbreviated version!
For detailed information about 3,5,7-trioxododecanoyl-CoA synthase, go to the full flat file.

Word Map on EC 2.3.1.206

Reaction

3 malonyl-CoA +

hexanoyl-CoA
= 3 CoA +
3,5,7-trioxododecanoyl-CoA
 + 3 CO2

Synonyms

OLA synthase, olivetol synthase, olivetol-forming PKS, OLS, PKS, polyketide synthase, tetraketide synthase, TKS, type III PKS, type III polyketide synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.206 3,5,7-trioxododecanoyl-CoA synthase

Application

Application on EC 2.3.1.206 - 3,5,7-trioxododecanoyl-CoA synthase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis
a synthetic pathway for the production of olivetolic acid in Escherichia coli is developed. Through combining OLA synthase and OLA cyclase expression with the required modules of a beta-oxidation reversal for hexanoyl-CoAgeneration, we demonstrate the in vivo synthesis of olivetolic acid from a single carbon source. The integration of additional auxiliary enzymes to increase hexanoyl-CoA and malonyl-CoA, along with evaluation of varying fermentation conditions enabled the synthesis of 80 mg/l olivetolic acid. Olivetolic acid has various pharmacological activities