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0.000015 - 0.0041
etomoxiryl-CoA
0.00003 - 0.319
malonyl-CoA
0.00004
C75-CoA
Rattus norvegicus
-
IC50: 0.00004 mM in muscle
0.00024
C75-CoA
Rattus norvegicus
-
IC50: 0.00024 mM recombinant isozyme L-CPT I
0.00025
C75-CoA
Homo sapiens
-
potent competitive inhibition, IC50: 0.00025 mM in INS(832/13) cells, binds tightly but reversibly to CPT I, C75 applied in vivo is transformed to C75-CoA and inhibits fatty acid oxidation, e.g. in pancreatic INS(823/13), m
0.00036
C75-CoA
Rattus norvegicus
-
IC50: 0.00036 mM recombinant isozyme M-CPT I, binds tightly but reversibly to CPT I, C75 applied in vivo is transformed to C75-CoA
0.00046
C75-CoA
Homo sapiens
-
IC50: 0.00046 mM in L6E9 myotubes, binds tightly but reversibly to CPT I, C75 applied in vivo is transformed to C75-CoA and inhibits fatty acid oxidation, e.g. in pancreatic INS(823/13), m
0.0007
C75-CoA
Rattus norvegicus
-
potent competitive inhibition, IC50: 0.0007 mM in liver
0.000015
etomoxiryl-CoA
Rattus norvegicus
-
IC50: 0.000015 mM in muscle
0.00025
etomoxiryl-CoA
Rattus norvegicus
-
IC50: 0.00025 mM in liver
0.00121 - 0.00287
etomoxiryl-CoA
Homo sapiens
-
IC50: 0.00121 mM in INS(832/13) cells, IC50: 0.00287 in L6E9 myotubes
0.0031
etomoxiryl-CoA
Rattus norvegicus
-
IC50: 0.0031 mM recombinant isozyme M-CPT I
0.0041
etomoxiryl-CoA
Rattus norvegicus
-
IC50: 0.0041 mM recombinant isozyme L-CPT I
0.00003
malonyl-CoA
Homo sapiens
-
-
0.00007
malonyl-CoA
Homo sapiens
-
Glu3, Leu23, and Ser24 in M-CPTI are important for malonyl-CoA inhibition and binding but not for calalysis. IC50: 0.00007 mM for wild-type enzyme, 0.01 mM for mutant enzyme E3A, 0.00015 for mutant enzyme H5A, 0.01 mM for mutant enzyme E3A/V19A/L23A/S24A,
0.00007
malonyl-CoA
Oncorhynchus mykiss
-
mitochondrial isolate from liver, high polyunsaturated fat diet
0.000079
malonyl-CoA
Oncorhynchus mykiss
-
CPT I, liver
0.000096
malonyl-CoA
Homo sapiens
-
wild-type protein, 1 mM carnitine, mitochondrial preparation
0.00011
malonyl-CoA
Oncorhynchus mykiss
-
mitochondrial isolate from liver, high saturated fat diet
0.000117
malonyl-CoA
Homo sapiens
-
wild-type protein, 0.683 mM carnitine, mitochondrial preparation
0.00012
malonyl-CoA
Oncorhynchus mykiss
-
mitochondrial isolate from liver, control diet
0.00019
malonyl-CoA
Homo sapiens
-
chimeric protein: residues 1-50 of pig enzyme recombined with human enzyme, mitochondrial preparation
0.00019
malonyl-CoA
Sus scrofa
-
mitochondria isolated from newborn pig, pH 7.2, 30°C
0.00021
malonyl-CoA
Sus scrofa
-
mitochondria isolated from adult pig, pH 7.2, 30°C
0.000246
malonyl-CoA
Homo sapiens
-
D17E mutant protein, 0.770 mM carnitine, mitochondrial preparation
0.00026
malonyl-CoA
Sus scrofa
-
mitochondria isolated from 24-h-old, fed pig, pH 7.2, 30°C
0.000279
malonyl-CoA
Homo sapiens
-
D17E mutant protein, 1 mM carnitine, mitochondrial preparation
0.000284
malonyl-CoA
Sus scrofa
-
E17D mutant protein, 0.606 mM carnitine, mitochondrial preparation
0.000297
malonyl-CoA
Sus scrofa
-
E17D mutant protein, 1 mM carnitine, mitochondrial preparation
0.000325
malonyl-CoA
Homo sapiens
-
chimeric protein: residues 1-128 of pig enzyme recombined with human enzyme, mitochondrial preparation
0.00035
malonyl-CoA
Oncorhynchus mykiss
-
mitochondrial isolate from red muscle, high polyunsaturated fat diet
0.000359
malonyl-CoA
Sus scrofa
-
chimeric protein: residues 1-128 of human enzyme recombined with pig enzyme, mitochondrial preparation
0.00037
malonyl-CoA
Oncorhynchus mykiss
-
CPT I, white muscle
0.0004
malonyl-CoA
Oncorhynchus mykiss
-
CPT I, heart
0.000457
malonyl-CoA
Sus scrofa
-
chimeric protein: residues 1-50 of human enzyme recombined with pig enzyme, mitochondrial preparation
0.0005
malonyl-CoA
Homo sapiens
-
IC50: 0.0005 mM for the recombinant wild-type enzyme
0.00052
malonyl-CoA
Homo sapiens
-
IC50: 0.00052 mM for the recombinant revertant A305C, IC50 values of recombinant mutant isozymes M-CPT I overview
0.00053
malonyl-CoA
Sus scrofa
-
mitochondria isolated from 24-h-old, fasted pig, pH 7.2, 30°C
0.00055
malonyl-CoA
Oncorhynchus mykiss
-
CPT I, red muscle
0.00055
malonyl-CoA
Sus scrofa
-
wild-type protein, 0.198 mM carnitine, mitochondrial preparation
0.00074
malonyl-CoA
Drosophila melanogaster
-
at 0.035 mM palmitoyl-CoA
0.00076
malonyl-CoA
Drosophila melanogaster
-
at 0.035 mM palmitoyl-CoA
0.000804
malonyl-CoA
Sus scrofa
-
wild-type protein, 1 mM carnitine, mitochondrial preparation
0.000906
malonyl-CoA
Sus scrofa
IC50: 906 nM
0.00101
malonyl-CoA
Drosophila melanogaster
-
at 0.07 mM palmitoyl-CoA
0.00119
malonyl-CoA
Oncorhynchus mykiss
-
mitochondrial isolate from red muscle, control diet
0.00183
malonyl-CoA
Oncorhynchus mykiss
-
mitochondrial isolate from red muscle, high saturated fat diet
0.00232
malonyl-CoA
Drosophila melanogaster
-
at 0.07 mM palmitoyl-CoA
0.00339
malonyl-CoA
Rattus norvegicus
IC50: 0.00339 mM for wild-type enzyme, 0.00021 mM for mutant enzyme E590A, 0.00039 mM for mutant enzyme E590Q, 0.00025 mM for mutant enzyme E590K
0.0073 - 0.0384
malonyl-CoA
Homo sapiens
-
IC50: 0.0073 mM for the recombinant wild-type isozyme CPT1A, IC50: 0.0384 mM for CPT1A mutant R243T, IC50 values of other mutants, overview, determination of two binding sites, the A site and the O site, the latter involved residue Arg243, binding struct
0.0087
malonyl-CoA
Rattus norvegicus
IC50 0.0087 mM for mutant enzyme N464D
0.01
malonyl-CoA
Ovis aries
IC50 for wild-type M-CPT-1 is 0.010 mM
0.0123
malonyl-CoA
Rattus norvegicus
IC50: 0.0123 for wild-type enzyme
0.015
malonyl-CoA
Rattus norvegicus
IC50 0.015 mM for mutant enzyme T314S
0.0252
malonyl-CoA
Macrobrachium borellii
-
10 min pre-incubation with malonyl-CoA
0.0275
malonyl-CoA
Rattus norvegicus
IC50 0.0275 mM for mutant enzyme C608A
0.0298
malonyl-CoA
Ovis aries
IC50 for wild-type L-CPT-1 is 0.0298 mM
0.03556
malonyl-CoA
Sus scrofa
-
protein with deletion of residue 1-18, mitochondrial preparation
0.03919
malonyl-CoA
Sus scrofa
-
protein with deletion of residue 1-28, mitochondrial preparation
0.0395
malonyl-CoA
Rattus norvegicus
IC50 0.0395 mM for mutant enzyme A478G
0.0768
malonyl-CoA
Rattus norvegicus
-
mitochondrial isolate
0.1058
malonyl-CoA
Macrobrachium borellii
-
without pre-incubation with malonyl-CoA
0.1103
malonyl-CoA
Rattus norvegicus
-
mitochondrial isolate, after incubation with protein kinase A
0.155
malonyl-CoA
Rattus norvegicus
IC50 0.155 mM for mutant enzyme M593A
0.319
malonyl-CoA
Rattus norvegicus
IC50 0.319 mM for mutant enzyme M593 mM